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Synthesis of natural phaeosphaeride A derivatives and an in vitro evaluation of their anti-cancer potential.
Bioorg Med Chem Lett. 2015 Dec 1;25(23):5566-9. doi: 10.1016/j.bmcl.2015.10.048. Epub 2015 Oct 19.
Bioorg Med Chem Lett. 2015.
PMID: 26508550
Synthesis and Biological Evaluation of Phaeosphaeride A Derivatives as Antitumor Agents.
Abzianidze V, Beltyukov P, Zakharenkova S, Moiseeva N, Mejia J, Holder A, Trishin Y, Berestetskiy A, Kuznetsov V.
Abzianidze V, et al.
Molecules. 2018 Nov 21;23(11):3043. doi: 10.3390/molecules23113043.
Molecules. 2018.
PMID: 30469343
Free PMC article.
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Crystal structure of natural phaeosphaeride A.
Abzianidze VV, Poluektova EV, Bolshakova KP, Panikorovskii TL, Bogachenkov AS, Berestetskiy AO.
Abzianidze VV, et al.
Acta Crystallogr E Crystallogr Commun. 2015 Jul 31;71(Pt 8):o625-6. doi: 10.1107/S205698901501395X. eCollection 2015 Aug 1.
Acta Crystallogr E Crystallogr Commun. 2015.
PMID: 26396831
Free PMC article.
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Towards lead compounds as anti-cancer agents via new phaeosphaeride A derivatives.
Abzianidze VV, Zakharenkova SA, Moiseeva NI, Beltyukov PP, Polukeev VA, Dubrovskii YA, Kuznetsov VA, Trishin YG, Mejia JE, Holder AA.
Abzianidze VV, et al.
Bioorg Med Chem Lett. 2019 Jan 1;29(1):59-61. doi: 10.1016/j.bmcl.2018.11.003. Epub 2018 Nov 9.
Bioorg Med Chem Lett. 2019.
PMID: 30447888
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Natural Phaeosphaeride A Derivatives Overcome Drug Resistance of Tumor Cells and Modulate Signaling Pathways.
Abzianidze V, Moiseeva N, Suponina D, Zakharenkova S, Rogovskaya N, Laletina L, Holder AA, Krivorotov D, Bogachenkov A, Garabadzhiu A, Ukolov A, Kosorukov V.
Abzianidze V, et al.
Pharmaceuticals (Basel). 2022 Mar 24;15(4):395. doi: 10.3390/ph15040395.
Pharmaceuticals (Basel). 2022.
PMID: 35455394
Free PMC article.
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4-Hydroxybenzyl modification of the highly teratogenic retinoid, 4-[(1E)-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl)-1-propen-1-yl]benzoic acid (TTNPB), yields a compound that induces apoptosis in breast cancer cells and shows reduced teratogenicity.
Anding AL, Nieves NJ, Abzianidze VV, Collins MD, Curley RW Jr, Clagett-Dame M.
Anding AL, et al. Among authors: abzianidze vv.
Chem Res Toxicol. 2011 Nov 21;24(11):1853-61. doi: 10.1021/tx200174n. Epub 2011 Oct 19.
Chem Res Toxicol. 2011.
PMID: 21939267
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5-bromo-2,3-dihydro-4-methyl-3-nitrothiophene 1,1-dioxide.
Strauss LH, Abzianidze VV, Berestovitskaya VM, Efremova IE.
Strauss LH, et al. Among authors: abzianidze vv.
Acta Crystallogr C. 2003 Mar;59(Pt 3):o177-8. doi: 10.1107/s0108270103000842. Epub 2003 Feb 28.
Acta Crystallogr C. 2003.
PMID: 12711801
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