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Imparting aromaticity to 2-pyridone derivatives by O-alkylation resulted in new competitive and non-competitive PIM-1 kinase inhibitors with caspase-activated apoptosis.
Abdelaziz ME, El-Miligy MMM, Fahmy SM, Abu-Serie MM, Hazzaa AA, Mahran MA. Abdelaziz ME, et al. Among authors: abu serie mm. J Enzyme Inhib Med Chem. 2024 Dec;39(1):2304044. doi: 10.1080/14756366.2024.2304044. Epub 2024 Jan 17. J Enzyme Inhib Med Chem. 2024. PMID: 38230430 Free PMC article.
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