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Des-acyl ghrelin fragments and analogues promote survival of pancreatic β-cells and human pancreatic islets and prevent diabetes in streptozotocin-treated rats.
Granata R, Settanni F, Julien M, Nano R, Togliatto G, Trombetta A, Gallo D, Piemonti L, Brizzi MF, Abribat T, van Der Lely AJ, Ghigo E. Granata R, et al. Among authors: abribat t. J Med Chem. 2012 Mar 22;55(6):2585-96. doi: 10.1021/jm201223m. Epub 2012 Mar 5. J Med Chem. 2012. PMID: 22352743 Free article.
Effects of acute administration of acylated and unacylated ghrelin on glucose and insulin concentrations in morbidly obese subjects without overt diabetes.
Kiewiet RM, van Aken MO, van der Weerd K, Uitterlinden P, Themmen AP, Hofland LJ, de Rijke YB, Delhanty PJ, Ghigo E, Abribat T, van der Lely AJ. Kiewiet RM, et al. Among authors: abribat t. Eur J Endocrinol. 2009 Oct;161(4):567-73. doi: 10.1530/EJE-09-0339. Epub 2009 Jul 23. Eur J Endocrinol. 2009. PMID: 19628651 Clinical Trial.
Safety, tolerability, pharmacokinetics and pharmacodynamics of AZP-531, a first-in-class analogue of unacylated ghrelin, in healthy and overweight/obese subjects and subjects with type 2 diabetes.
Allas S, Delale T, Ngo N, Julien M, Sahakian P, Ritter J, Abribat T, van der Lely AJ. Allas S, et al. Among authors: abribat t. Diabetes Obes Metab. 2016 Sep;18(9):868-74. doi: 10.1111/dom.12675. Epub 2016 May 26. Diabetes Obes Metab. 2016. PMID: 27063928 Clinical Trial.
Administration of acylated ghrelin reduces insulin sensitivity, whereas the combination of acylated plus unacylated ghrelin strongly improves insulin sensitivity.
Gauna C, Meyler FM, Janssen JA, Delhanty PJ, Abribat T, van Koetsveld P, Hofland LJ, Broglio F, Ghigo E, van der Lely AJ. Gauna C, et al. Among authors: abribat t. J Clin Endocrinol Metab. 2004 Oct;89(10):5035-42. doi: 10.1210/jc.2004-0363. J Clin Endocrinol Metab. 2004. PMID: 15472202 Clinical Trial.
50 results