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Matrix metalloproteinase-12 is a therapeutic target for asthma in children and young adults.
Mukhopadhyay S, Sypek J, Tavendale R, Gartner U, Winter J, Li W, Page K, Fleming M, Brady J, O'Toole M, Macgregor DF, Goldman S, Tam S, Abraham W, Williams C, Miller DK, Palmer CN. Mukhopadhyay S, et al. Among authors: abraham w. J Allergy Clin Immunol. 2010 Jul;126(1):70-6.e16. doi: 10.1016/j.jaci.2010.03.027. Epub 2010 May 23. J Allergy Clin Immunol. 2010. PMID: 20546881
Discovery of a potent and selective prostaglandin D2 receptor antagonist, [(3R)-4-(4-chloro-benzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]-acetic acid (MK-0524).
Sturino CF, O'Neill G, Lachance N, Boyd M, Berthelette C, Labelle M, Li L, Roy B, Scheigetz J, Tsou N, Aubin Y, Bateman KP, Chauret N, Day SH, Lévesque JF, Seto C, Silva JH, Trimble LA, Carriere MC, Denis D, Greig G, Kargman S, Lamontagne S, Mathieu MC, Sawyer N, Slipetz D, Abraham WM, Jones T, McAuliffe M, Piechuta H, Nicoll-Griffith DA, Wang Z, Zamboni R, Young RN, Metters KM. Sturino CF, et al. J Med Chem. 2007 Feb 22;50(4):794-806. doi: 10.1021/jm0603668. J Med Chem. 2007. PMID: 17300164
L-454,560, a potent and selective PDE4 inhibitor with in vivo efficacy in animal models of asthma and cognition.
Huang Z, Dias R, Jones T, Liu S, Styhler A, Claveau D, Otu F, Ng K, Laliberte F, Zhang L, Goetghebeur P, Abraham WM, Macdonald D, Dubé D, Gallant M, Lacombe P, Girard Y, Young RN, Turner MJ, Nicholson DW, Mancini JA. Huang Z, et al. Among authors: abraham wm. Biochem Pharmacol. 2007 Jun 15;73(12):1971-81. doi: 10.1016/j.bcp.2007.03.010. Epub 2007 Mar 16. Biochem Pharmacol. 2007. PMID: 17428447
Inhibition of spleen tyrosine kinase attenuates allergen-mediated airway constriction.
Moy LY, Jia Y, Caniga M, Lieber G, Gil M, Fernandez X, Sirkowski E, Miller R, Alexander JP, Lee HH, Shin JD, Ellis JM, Chen H, Wilhelm A, Yu H, Vincent S, Chapman RW, Kelly N, Hickey E, Abraham WM, Northrup A, Miller T, Houshyar H, Crackower MA. Moy LY, et al. Among authors: abraham wm. Am J Respir Cell Mol Biol. 2013 Dec;49(6):1085-92. doi: 10.1165/rcmb.2013-0200OC. Am J Respir Cell Mol Biol. 2013. PMID: 23889698
Design of Cytotoxic T Cell Epitopes by Machine Learning of Human Degrons.
Truex NL, Mohapatra S, Melo M, Rodriguez J, Li N, Abraham W, Sementa D, Touti F, Keskin DB, Wu CJ, Irvine DJ, Gómez-Bombarelli R, Pentelute BL. Truex NL, et al. Among authors: abraham w. ACS Cent Sci. 2024 Mar 6;10(4):793-802. doi: 10.1021/acscentsci.3c01544. eCollection 2024 Apr 24. ACS Cent Sci. 2024. PMID: 38680558 Free PMC article.
Directed evolution-based discovery of ligands for in vivo restimulation of CAR-T cells.
Ma L, Ramasubramanian R, Mehta N, Cossette B, Morgan D, Sukaj I, Bergaggio E, Kadauke S, Myers R, Paruzzo L, Ghilardi G, Grzywa T, Cozzone A, Schuster S, Frey N, Zhang L, Yousefpour P, Abraham W, Suh H, Ruella M, Grupp S, Chiarle R, Wittrup KD, Irvine DJ. Ma L, et al. Among authors: abraham w. bioRxiv [Preprint]. 2024 Apr 30:2024.04.16.589780. doi: 10.1101/2024.04.16.589780. bioRxiv. 2024. PMID: 38659938 Free PMC article. Preprint.
1,243 results