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Legionella pneumophila S1P-lyase targets host sphingolipid metabolism and restrains autophagy.
Rolando M, Escoll P, Nora T, Botti J, Boitez V, Bedia C, Daniels C, Abraham G, Stogios PJ, Skarina T, Christophe C, Dervins-Ravault D, Cazalet C, Hilbi H, Rupasinghe TW, Tull D, McConville MJ, Ong SY, Hartland EL, Codogno P, Levade T, Naderer T, Savchenko A, Buchrieser C. Rolando M, et al. Among authors: abraham g. Proc Natl Acad Sci U S A. 2016 Feb 16;113(7):1901-6. doi: 10.1073/pnas.1522067113. Epub 2016 Feb 1. Proc Natl Acad Sci U S A. 2016. PMID: 26831115 Free PMC article.
Eliminating Legionella by inhibiting BCL-XL to induce macrophage apoptosis.
Speir M, Lawlor KE, Glaser SP, Abraham G, Chow S, Vogrin A, Schulze KE, Schuelein R, O'Reilly LA, Mason K, Hartland EL, Lithgow T, Strasser A, Lessene G, Huang DC, Vince JE, Naderer T. Speir M, et al. Among authors: abraham g. Nat Microbiol. 2016 Feb 24;1:15034. doi: 10.1038/nmicrobiol.2015.34. Nat Microbiol. 2016. PMID: 27572165
Targeting of RNA Polymerase II by a nuclear Legionella pneumophila Dot/Icm effector SnpL.
Schuelein R, Spencer H, Dagley LF, Li PF, Luo L, Stow JL, Abraham G, Naderer T, Gomez-Valero L, Buchrieser C, Sugimoto C, Yamagishi J, Webb AI, Pasricha S, Hartland EL. Schuelein R, et al. Among authors: abraham g. Cell Microbiol. 2018 Sep;20(9):e12852. doi: 10.1111/cmi.12852. Epub 2018 May 18. Cell Microbiol. 2018. PMID: 29691989
Mpeg1 is not essential for antibacterial or antiviral immunity, but is implicated in antigen presentation.
Ebrahimnezhaddarzi S, Bird CH, Allison CC, Tuipulotu DE, Kostoulias X, Macri C, Stutz MD, Abraham G, Kaiserman D, Pang SS, Man SM, Mintern JD, Naderer T, Peleg AY, Pellegrini M, Whisstock JC, Bird PI. Ebrahimnezhaddarzi S, et al. Among authors: abraham g. Immunol Cell Biol. 2022 Aug;100(7):529-546. doi: 10.1111/imcb.12554. Epub 2022 May 12. Immunol Cell Biol. 2022. PMID: 35471730 Free PMC article.
A1 is induced by pathogen ligands to limit myeloid cell death and NLRP3 inflammasome activation.
Speir M, Tye H, Gottschalk TA, Simpson DS, Djajawi TM, Deo P, Ambrose RL, Conos SA, Emery J, Abraham G, Pascoe A, Hughes SA, Weir A, Hawkins ED, Kong I, Herold MJ, Pearson JS, Lalaoui N, Naderer T, Vince JE, Lawlor KE. Speir M, et al. Among authors: abraham g. EMBO Rep. 2023 Nov 6;24(11):e56865. doi: 10.15252/embr.202356865. Epub 2023 Oct 17. EMBO Rep. 2023. PMID: 37846472 Free PMC article.
Nucleic acid liquids.
Abraham G, Chaderjian A, Nguyen A, Wilken S, Saleh OA. Abraham G, et al. Rep Prog Phys. 2024 May 2. doi: 10.1088/1361-6633/ad4662. Online ahead of print. Rep Prog Phys. 2024. PMID: 38697088
An enhanced IL17 and muted type I interferon nasal epithelial cell state characterizes severe COVID-19 with fungal coinfection.
Ziegler CGK, Owings AH, Galeas-Pena M, Kazer SW, Miao VN, Navia AW, Tang Y, Bromley JD, Lotfy P, Sloan M, Laird H, Williams HB, George M, Drake RS, Pride Y, Abraham GE 3rd, Senitko M, Robinson TO, Diamond G, Lionakis MS, Shalek AK, Ordovas-Montanes J, Horwitz BH, Glover SC. Ziegler CGK, et al. Among authors: abraham ge 3rd. Microbiol Spectr. 2024 Apr 30:e0351623. doi: 10.1128/spectrum.03516-23. Online ahead of print. Microbiol Spectr. 2024. PMID: 38687064 Free article.
1,192 results