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Identification of the GPR55 antagonist binding site using a novel set of high-potency GPR55 selective ligands.
Kotsikorou E, Sharir H, Shore DM, Hurst DP, Lynch DL, Madrigal KE, Heynen-Genel S, Milan LB, Chung TD, Seltzman HH, Bai Y, Caron MG, Barak LS, Croatt MP, Abood ME, Reggio PH. Kotsikorou E, et al. Among authors: abood me. Biochemistry. 2013 Dec 31;52(52):9456-69. doi: 10.1021/bi4008885. Epub 2013 Dec 17. Biochemistry. 2013. PMID: 24274581 Free PMC article.
Design, synthesis, and analysis of antagonists of GPR55: Piperidine-substituted 1,3,4-oxadiazol-2-ones.
Meza-Aviña ME, Lingerfelt MA, Console-Bram LM, Gamage TF, Sharir H, Gettys KE, Hurst DP, Kotsikorou E, Shore DM, Caron MG, Rao N, Barak LS, Abood ME, Reggio PH, Croatt MP. Meza-Aviña ME, et al. Among authors: abood me. Bioorg Med Chem Lett. 2016 Apr 1;26(7):1827-1830. doi: 10.1016/j.bmcl.2016.02.030. Epub 2016 Feb 16. Bioorg Med Chem Lett. 2016. PMID: 26916440 Free PMC article.
Structure-activity relationships of benzothiazole GPR35 antagonists.
Abdalhameed MM, Zhao P, Hurst DP, Reggio PH, Abood ME, Croatt MP. Abdalhameed MM, et al. Among authors: abood me. Bioorg Med Chem Lett. 2017 Feb 1;27(3):612-615. doi: 10.1016/j.bmcl.2016.12.012. Epub 2016 Dec 5. Bioorg Med Chem Lett. 2017. PMID: 27989666 Free PMC article.
Therapeutic Exploitation of GPR18: Beyond the Cannabinoids?
Morales P, Lago-Fernandez A, Hurst DP, Sotudeh N, Brailoiu E, Reggio PH, Abood ME, Jagerovic N. Morales P, et al. Among authors: abood me. J Med Chem. 2020 Dec 10;63(23):14216-14227. doi: 10.1021/acs.jmedchem.0c00926. Epub 2020 Sep 23. J Med Chem. 2020. PMID: 32914978 Free PMC article. Review.
Design, synthesis and biological evaluation of GPR55 agonists.
Fakhouri L, Cook CD, Al-Huniti MH, Console-Bram LM, Hurst DP, Spano MBS, Nasrallah DJ, Caron MG, Barak LS, Reggio PH, Abood ME, Croatt MP. Fakhouri L, et al. Among authors: abood me. Bioorg Med Chem. 2017 Aug 15;25(16):4355-4367. doi: 10.1016/j.bmc.2017.06.016. Epub 2017 Jun 13. Bioorg Med Chem. 2017. PMID: 28673732 Free PMC article.
133 results