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A novel pyrazolo[1,5-a]pyrimidine is a potent inhibitor of cyclin-dependent protein kinases 1, 2, and 9, which demonstrates antitumor effects in human tumor xenografts following oral administration.
Heathcote DA, Patel H, Kroll SH, Hazel P, Periyasamy M, Alikian M, Kanneganti SK, Jogalekar AS, Scheiper B, Barbazanges M, Blum A, Brackow J, Siwicka A, Pace RD, Fuchter MJ, Snyder JP, Liotta DC, Freemont PS, Aboagye EO, Coombes RC, Barrett AG, Ali S. Heathcote DA, et al. Among authors: aboagye eo. J Med Chem. 2010 Dec 23;53(24):8508-22. doi: 10.1021/jm100732t. Epub 2010 Nov 16. J Med Chem. 2010. PMID: 21080703
Inhibiting estrogen responses in breast cancer cells using a fusion protein encoding estrogen receptor-alpha and the transcriptional repressor PLZF.
Buluwela L, Pike J, Mazhar D, Kamalati T, Hart SM, Al-Jehani R, Yahaya H, Patel N, Sarwar N, Heathcote DA, Schwickerath O, Phoenix F, Hill R, Aboagye E, Shousha S, Waxman J, Lemoine NR, Zelent A, Coombes RC, Ali S. Buluwela L, et al. Gene Ther. 2005 Mar;12(5):452-60. doi: 10.1038/sj.gt.3302421. Gene Ther. 2005. PMID: 15647773
Phase I trial of the positron-emitting Arg-Gly-Asp (RGD) peptide radioligand 18F-AH111585 in breast cancer patients.
Kenny LM, Coombes RC, Oulie I, Contractor KB, Miller M, Spinks TJ, McParland B, Cohen PS, Hui AM, Palmieri C, Osman S, Glaser M, Turton D, Al-Nahhas A, Aboagye EO. Kenny LM, et al. Among authors: aboagye eo. J Nucl Med. 2008 Jun;49(6):879-86. doi: 10.2967/jnumed.107.049452. Epub 2008 May 15. J Nucl Med. 2008. PMID: 18483090 Free article. Clinical Trial.
The development of a selective cyclin-dependent kinase inhibitor that shows antitumor activity.
Ali S, Heathcote DA, Kroll SH, Jogalekar AS, Scheiper B, Patel H, Brackow J, Siwicka A, Fuchter MJ, Periyasamy M, Tolhurst RS, Kanneganti SK, Snyder JP, Liotta DC, Aboagye EO, Barrett AG, Coombes RC. Ali S, et al. Among authors: aboagye eo. Cancer Res. 2009 Aug 1;69(15):6208-15. doi: 10.1158/0008-5472.CAN-09-0301. Epub 2009 Jul 28. Cancer Res. 2009. PMID: 19638587 Free PMC article.
Translational imaging of apoptosis.
Smith G, Nguyen QD, Aboagye EO. Smith G, et al. Among authors: aboagye eo. Anticancer Agents Med Chem. 2009 Nov;9(9):958-67. doi: 10.2174/187152009789377709. Anticancer Agents Med Chem. 2009. PMID: 19663785 Review.
301 results