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Clathrin-associated AP-1 controls termination of STING signalling.
Liu Y, Xu P, Rivara S, Liu C, Ricci J, Ren X, Hurley JH, Ablasser A. Liu Y, et al. Among authors: ablasser a. Nature. 2022 Oct;610(7933):761-767. doi: 10.1038/s41586-022-05354-0. Epub 2022 Oct 19. Nature. 2022. PMID: 36261523 Free PMC article.
Signalling strength determines proapoptotic functions of STING.
Gulen MF, Koch U, Haag SM, Schuler F, Apetoh L, Villunger A, Radtke F, Ablasser A. Gulen MF, et al. Among authors: ablasser a. Nat Commun. 2017 Sep 5;8(1):427. doi: 10.1038/s41467-017-00573-w. Nat Commun. 2017. PMID: 28874664 Free PMC article.
Targeting STING with covalent small-molecule inhibitors.
Haag SM, Gulen MF, Reymond L, Gibelin A, Abrami L, Decout A, Heymann M, van der Goot FG, Turcatti G, Behrendt R, Ablasser A. Haag SM, et al. Among authors: ablasser a. Nature. 2018 Jul;559(7713):269-273. doi: 10.1038/s41586-018-0287-8. Epub 2018 Jul 4. Nature. 2018. PMID: 29973723
Intracellular bacteria engage a STING-TBK1-MVB12b pathway to enable paracrine cGAS-STING signalling.
Nandakumar R, Tschismarov R, Meissner F, Prabakaran T, Krissanaprasit A, Farahani E, Zhang BC, Assil S, Martin A, Bertrams W, Holm CK, Ablasser A, Klause T, Thomsen MK, Schmeck B, Howard KA, Henry T, Gothelf KV, Decker T, Paludan SR. Nandakumar R, et al. Among authors: ablasser a. Nat Microbiol. 2019 Apr;4(4):701-713. doi: 10.1038/s41564-019-0367-z. Epub 2019 Feb 25. Nat Microbiol. 2019. PMID: 30804548 Free PMC article.
Structural mechanism of cGAS inhibition by the nucleosome.
Pathare GR, Decout A, Glück S, Cavadini S, Makasheva K, Hovius R, Kempf G, Weiss J, Kozicka Z, Guey B, Melenec P, Fierz B, Thomä NH, Ablasser A. Pathare GR, et al. Among authors: ablasser a. Nature. 2020 Nov;587(7835):668-672. doi: 10.1038/s41586-020-2750-6. Epub 2020 Sep 10. Nature. 2020. PMID: 32911482
COPA silences STING.
Rivara S, Ablasser A. Rivara S, et al. Among authors: ablasser a. J Exp Med. 2020 Nov 2;217(11):e20201517. doi: 10.1084/jem.20201517. J Exp Med. 2020. PMID: 32991673 Free PMC article.
The cGAS-STING pathway drives type I IFN immunopathology in COVID-19.
Domizio JD, Gulen MF, Saidoune F, Thacker VV, Yatim A, Sharma K, Nass T, Guenova E, Schaller M, Conrad C, Goepfert C, de Leval L, Garnier CV, Berezowska S, Dubois A, Gilliet M, Ablasser A. Domizio JD, et al. Among authors: ablasser a. Nature. 2022 Mar;603(7899):145-151. doi: 10.1038/s41586-022-04421-w. Epub 2022 Jan 19. Nature. 2022. PMID: 35045565 Free PMC article.
60 results