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Page 1
Showing results for abeta y
Search for Abetu Y instead (3 results)
Salidroside attenuates neuronal ferroptosis by activating the Nrf2/HO1 signaling pathway in Abeta(1-42)-induced Alzheimer's disease mice and glutamate-injured HT22 cells.
Yang S, Xie Z, Pei T, Zeng Y, Xiong Q, Wei H, Wang Y, Cheng W. Yang S, et al. Chin Med. 2022 Jul 4;17(1):82. doi: 10.1186/s13020-022-00634-3. Chin Med. 2022. PMID: 35787281 Free PMC article.
Malondialdehyde, reduced glutathione, oxidized glutathione disulfide, and superoxide dismutase were measured. The novel object recognition test, Y-maze, and open field test were used to investigate the protective effects of salidroside on Abeta(1-42)-induced WT and …
Malondialdehyde, reduced glutathione, oxidized glutathione disulfide, and superoxide dismutase were measured. The novel object recognition t …
Gossypetin ameliorates 5xFAD spatial learning and memory through enhanced phagocytosis against Abeta.
Jo KW, Lee D, Cha DG, Oh E, Choi YH, Kim S, Park ES, Kim JK, Kim KT. Jo KW, et al. Alzheimers Res Ther. 2022 Oct 21;14(1):158. doi: 10.1186/s13195-022-01096-3. Alzheimers Res Ther. 2022. PMID: 36271414 Free PMC article.
Microglia constantly scavenge various waste materials in the brain including damaged or apoptotic neurons and Abeta. Through phagocytosis of Abeta, microglia prevent the accumulation of Abeta plaque in the brain. ...Since microglia play an important role in …
Microglia constantly scavenge various waste materials in the brain including damaged or apoptotic neurons and Abeta. Through phagocyt …
The VCAM1-ApoE pathway directs microglial chemotaxis and alleviates Alzheimer's disease pathology.
Lau SF, Wu W, Wong HY, Ouyang L, Qiao Y, Xu J, Lau JH, Wong C, Jiang Y, Holtzman DM, Fu AKY, Ip NY. Lau SF, et al. Nat Aging. 2023 Oct;3(10):1219-1236. doi: 10.1038/s43587-023-00491-1. Epub 2023 Sep 21. Nat Aging. 2023. PMID: 37735240 Free PMC article.
Here, we show that IL-33 induces VCAM1 in microglia, which promotes microglial chemotaxis toward amyloid-beta (Abeta) plaque-associated ApoE, and leads to Abeta clearance. We show that IL-33 stimulates a chemotactic state in microglia, characterized by Abeta- …
Here, we show that IL-33 induces VCAM1 in microglia, which promotes microglial chemotaxis toward amyloid-beta (Abeta) plaque-associat …
Huperzine A and Its Neuroprotective Molecular Signaling in Alzheimer's Disease.
Friedli MJ, Inestrosa NC. Friedli MJ, et al. Molecules. 2021 Oct 29;26(21):6531. doi: 10.3390/molecules26216531. Molecules. 2021. PMID: 34770940 Free PMC article. Review.
Here, we summarize the neuroprotective effects of HupA on AD, with an emphasis on its interactions with different molecular signaling avenues, such as the Wnt signaling, the pre- and post-synaptic region mechanisms (synaptotagmin, neuroligins), the amyloid precursor protein (APP) …
Here, we summarize the neuroprotective effects of HupA on AD, with an emphasis on its interactions with different molecular signaling avenue …
The S1P receptor 1 antagonist Ponesimod reduces TLR4-induced neuroinflammation and increases Abeta clearance in 5XFAD mice.
Zhu Z, Zhang L, Elsherbini A, Crivelli SM, Tripathi P, Harper C, Quadri Z, Spassieva SD, Bieberich E. Zhu Z, et al. EBioMedicine. 2023 Aug;94:104713. doi: 10.1016/j.ebiom.2023.104713. Epub 2023 Jul 20. EBioMedicine. 2023. PMID: 37480622 Free PMC article.
FINDINGS: Abeta(42) increased the levels of TLR4 and S1PR1, leading to their complex formation. ...It also increased the level of IL-33, an anti-inflammatory cytokine that promotes Abeta(42) phagocytosis by microglia. As a result of these changes, Ponesimod decrease …
FINDINGS: Abeta(42) increased the levels of TLR4 and S1PR1, leading to their complex formation. ...It also increased the level of IL- …
Telmisartan Alleviates Alzheimer's Disease-Related Neuropathologies and Cognitive Impairments.
Fu XX, Wei B, Cao HM, Duan R, Deng Y, Lian HW, Zhang YD, Jiang T. Fu XX, et al. J Alzheimers Dis. 2023;94(3):919-933. doi: 10.3233/JAD-230133. J Alzheimers Dis. 2023. PMID: 37355897
Specifically, components involved in Abeta production and degradation pathway were analyzed to explore the mechanisms underlying the therapeutic effect of TEL against Abeta pathology. ...The favorable effects of TEL on Abeta pathology were achieved by inhibit …
Specifically, components involved in Abeta production and degradation pathway were analyzed to explore the mechanisms underlying the …
Passive Immunotherapies Targeting Amyloid-β in Alzheimer's Disease: A Quantitative Systems Pharmacology Perspective.
Marković M, Milošević J, Wang W, Cao Y. Marković M, et al. Mol Pharmacol. 2023 Dec 15;105(1):1-13. doi: 10.1124/molpharm.123.000726. Mol Pharmacol. 2023. PMID: 37907353 Review.
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by amyloid-beta (Abeta) protein accumulation in the brain. Passive immunotherapies using monoclonal antibodies for targeting Abeta have shown promise for AD treatment. ...Subsequently, we develop …
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by amyloid-beta (Abeta) protein accumulation in the brain. Pas …
Neuroprotective effect of dexmedetomidine on autophagy in mice administered intracerebroventricular injections of Abeta(25-35).
Lee YY, Han JI, Lee KE, Cho S, Suh EC. Lee YY, et al. Front Pharmacol. 2023 Aug 17;14:1184776. doi: 10.3389/fphar.2023.1184776. eCollection 2023. Front Pharmacol. 2023. PMID: 37663257 Free PMC article.
We hypothesized that Dex administration would have neuroprotective effects by improving pathological autophagy dysfunction in mice that received an intracerebroventricular (i.c.v.) injection of amyloid beta-protein fragment 25-35 (Abeta(25-35)) and in an autophagy-deficien …
We hypothesized that Dex administration would have neuroprotective effects by improving pathological autophagy dysfunction in mice that rece …
Abeta(1-42) peptides blunt the adenosine A(2A) receptor-mediated control of the interplay between P(2)X(7) and P(2)Y(1) receptors mediated calcium responses in astrocytes.
Dias L, Madeira D, Dias R, Tomé ÂR, Cunha RA, Agostinho P. Dias L, et al. Cell Mol Life Sci. 2022 Jul 30;79(8):457. doi: 10.1007/s00018-022-04492-y. Cell Mol Life Sci. 2022. PMID: 35907034
In primary cultures of rat astrocytes exposed to Abeta(1-42), ATP-evoked Ca(2+) responses had a lower amplitude but a longer duration than in control astrocytes and involved P(2)X(7)R and P(2)Y(1)R, the former potentiating the later. Moreover, Abeta(1-42) exp …
In primary cultures of rat astrocytes exposed to Abeta(1-42), ATP-evoked Ca(2+) responses had a lower amplitude but a longer duration …
Assessing Reactive Astrogliosis with 18F-SMBT-1 Across the Alzheimer Disease Spectrum.
Villemagne VL, Harada R, Doré V, Furumoto S, Mulligan R, Kudo Y, Burnham S, Krishnadas N, Bourgeat P, Xia Y, Laws S, Bozinovski S, Huang K, Ikonomovic MD, Fripp J, Yanai K, Okamura N, Rowe CC. Villemagne VL, et al. J Nucl Med. 2022 Oct;63(10):1560-1569. doi: 10.2967/jnumed.121.263255. Epub 2022 Jan 27. J Nucl Med. 2022. PMID: 35086892 Free PMC article.
Methods: We assessed (18)F-SMBT-1 PET regional binding in 77 volunteers (76 5.5 y old; 41 women, 36 men) across the AD continuum: 57 who were cognitively normal (CN) (44 amyloid-beta [Abeta]-negative [Abeta-] and 13 Abeta-positive [Abeta+]), 12 …
Methods: We assessed (18)F-SMBT-1 PET regional binding in 77 volunteers (76 5.5 y old; 41 women, 36 men) across the AD continuum: 57 …
1,641 results