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Papaverine identified as an inhibitor of high mobility group box 1/receptor for advanced glycation end-products interaction suppresses high mobility group box 1-mediated inflammatory responses.
Tamada K, Nakajima S, Ogawa N, Inada M, Shibasaki H, Sato A, Takasawa R, Yoshimori A, Suzuki Y, Watanabe N, Oyama T, Abe H, Inoue S, Abe T, Yokomizo T, Tanuma S. Tamada K, et al. Among authors: abe h, abe t. Biochem Biophys Res Commun. 2019 Apr 9;511(3):665-670. doi: 10.1016/j.bbrc.2019.01.136. Epub 2019 Feb 27. Biochem Biophys Res Commun. 2019. PMID: 30826057
Trimebutine attenuates high mobility group box 1-receptor for advanced glycation end-products inflammatory signaling pathways.
Nakajima S, Ogawa N, Yokoue N, Tachibana H, Tamada K, Okazawa M, Sato A, Oyama T, Abe H, Kamiya T, Yoshimori A, Yoshizawa K, Inoue S, Yokomizo T, Uchiumi F, Abe T, Tanuma SI. Nakajima S, et al. Among authors: abe h, abe t. Biochem Biophys Res Commun. 2020 Dec 17;533(4):1155-1161. doi: 10.1016/j.bbrc.2020.09.126. Epub 2020 Oct 8. Biochem Biophys Res Commun. 2020. PMID: 33041002
A 3-styrylchromone converted from trimebutine 3D pharmacophore possesses dual suppressive effects on RAGE and TLR4 signaling pathways.
Okazawa M, Oyama T, Abe H, Yamazaki H, Yoshimori A, Tsukimoto M, Yoshizawa K, Takao K, Sugita Y, Kamiya T, Uchiumi F, Sakagami H, Abe T, Tanuma SI. Okazawa M, et al. Among authors: abe h, abe t. Biochem Biophys Res Commun. 2021 Aug 20;566:1-8. doi: 10.1016/j.bbrc.2021.05.096. Epub 2021 Jun 7. Biochem Biophys Res Commun. 2021. PMID: 34111666
8,885 results