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Forced enhancer-promoter rewiring to alter gene expression in animal models.
Peslak SA, Demirci S, Chandra V, Ryu B, Bhardwaj SK, Jiang J, Rupon JW, Throm RE, Uchida N, Leonard A, Essawi K, Bonifacino AC, Krouse AE, Linde NS, Donahue RE, Ferrara F, Wielgosz M, Abdulmalik O, Hamagami N, Germino-Watnick P, Le A, Chu R, Hinds M, Weiss MJ, Tong W, Tisdale JF, Blobel GA. Peslak SA, et al. Among authors: abdulmalik o. Mol Ther Nucleic Acids. 2023 Jan 31;31:452-465. doi: 10.1016/j.omtn.2023.01.016. eCollection 2023 Mar 14. Mol Ther Nucleic Acids. 2023. PMID: 36852088 Free PMC article.
Quantitative assessment of the in-vitro binding kinetics of antisickling aromatic aldehydes with hemoglobin A: A universal HPLC-UV/Vis method to quantitate Schiff-base adduct formation.
Xu X, Ghatge MS, Huang B, Alghamdi A, Wang H, Pierce BD, Abdulmalik O, Zhang Y, Safo MK, Venitz J. Xu X, et al. Among authors: abdulmalik o. J Pharm Biomed Anal. 2023 Jan 20;223:115152. doi: 10.1016/j.jpba.2022.115152. Epub 2022 Nov 11. J Pharm Biomed Anal. 2023. PMID: 36399908 Free PMC article.
Design, Synthesis, and Investigation of Novel Nitric Oxide (NO)-Releasing Aromatic Aldehydes as Drug Candidates for the Treatment of Sickle Cell Disease.
Huang B, Ghatge MS, Donkor AK, Musayev FN, Deshpande TM, Al-Awadh M, Alhashimi RT, Zhu H, Omar AM, Telen MJ, Zhang Y, McMahon TJ, Abdulmalik O, Safo MK. Huang B, et al. Among authors: abdulmalik o. Molecules. 2022 Oct 12;27(20):6835. doi: 10.3390/molecules27206835. Molecules. 2022. PMID: 36296435 Free PMC article.
Elevated sphingosine-1-phosphate promotes sickling and sickle cell disease progression.
Zhang Y, Berka V, Song A, Sun K, Wang W, Zhang W, Ning C, Li C, Zhang Q, Bogdanov M, Alexander DC, Milburn MV, Ahmed MH, Lin H, Idowu M, Zhang J, Kato GJ, Abdulmalik OY, Zhang W, Dowhan W, Kellems RE, Zhang P, Jin J, Safo M, Tsai AL, Juneja HS, Xia Y. Zhang Y, et al. J Clin Invest. 2014 Jun;124(6):2750-61. doi: 10.1172/JCI74604. Epub 2014 May 16. J Clin Invest. 2014. PMID: 24837436 Free PMC article.
Structural and Functional Insight of Sphingosine 1-Phosphate-Mediated Pathogenic Metabolic Reprogramming in Sickle Cell Disease.
Sun K, D'Alessandro A, Ahmed MH, Zhang Y, Song A, Ko TP, Nemkov T, Reisz JA, Wu H, Adebiyi M, Peng Z, Gong J, Liu H, Huang A, Wen YE, Wen AQ, Berka V, Bogdanov MV, Abdulmalik O, Han L, Tsai AL, Idowu M, Juneja HS, Kellems RE, Dowhan W, Hansen KC, Safo MK, Xia Y. Sun K, et al. Among authors: abdulmalik o. Sci Rep. 2017 Nov 10;7(1):15281. doi: 10.1038/s41598-017-13667-8. Sci Rep. 2017. PMID: 29127281 Free PMC article.
Structure of fully liganded Hb ζ2β2s trapped in a tense conformation.
Safo MK, Ko TP, Abdulmalik O, He Z, Wang AH, Schreiter ER, Russell JE. Safo MK, et al. Among authors: abdulmalik o. Acta Crystallogr D Biol Crystallogr. 2013 Oct;69(Pt 10):2061-71. doi: 10.1107/S0907444913019197. Epub 2013 Sep 20. Acta Crystallogr D Biol Crystallogr. 2013. PMID: 24100324 Free PMC article.
83 results