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Discovery of novel oxazole-based macrocycles as anti-coronaviral agents targeting SARS-CoV-2 main protease.
Al-Wahaibi LH, Mostafa A, Mostafa YA, Abou-Ghadir OF, Abdelazeem AH, Gouda AM, Kutkat O, Abo Shama NM, Shehata M, Gomaa HAM, Abdelrahman MH, Mohamed FAM, Gu X, Ali MA, Trembleau L, Youssif BGM. Al-Wahaibi LH, et al. Among authors: abdelrahman mh. Bioorg Chem. 2021 Nov;116:105363. doi: 10.1016/j.bioorg.2021.105363. Epub 2021 Sep 17. Bioorg Chem. 2021. PMID: 34555629 Free PMC article.
Design, synthesis, and biological evaluation of novel EGFR inhibitors containing 5-chloro-3-hydroxymethyl-indole-2-carboxamide scaffold with apoptotic antiproliferative activity.
Mohamed FAM, Gomaa HAM, Hendawy OM, Ali AT, Farghaly HS, Gouda AM, Abdelazeem AH, Abdelrahman MH, Trembleau L, Youssif BGM. Mohamed FAM, et al. Among authors: abdelrahman mh. Bioorg Chem. 2021 Jul;112:104960. doi: 10.1016/j.bioorg.2021.104960. Epub 2021 May 1. Bioorg Chem. 2021. PMID: 34020242
Optimization and SAR investigation of novel 2,3-dihydropyrazino[1,2-a]indole-1,4-dione derivatives as EGFR and BRAFV600E dual inhibitors with potent antiproliferative and antioxidant activities.
Gomaa HAM, Shaker ME, Alzarea SI, Hendawy OM, Mohamed FAM, Gouda AM, Ali AT, Morcoss MM, Abdelrahman MH, Trembleau L, Youssif BGM. Gomaa HAM, et al. Among authors: abdelrahman mh. Bioorg Chem. 2022 Mar;120:105616. doi: 10.1016/j.bioorg.2022.105616. Epub 2022 Jan 19. Bioorg Chem. 2022. PMID: 35078049
Design, synthesis, mechanistic and histopathological studies of small-molecules of novel indole-2-carboxamides and pyrazino[1,2-a]indol-1(2H)-ones as potential anticancer agents effecting the reactive oxygen species production.
Youssif BGM, Abdelrahman MH, Abdelazeem AH, Abdelgawad MA, Ibrahim HM, Salem OIA, Mohamed MFA, Treambleau L, Bukhari SNA. Youssif BGM, et al. Among authors: abdelrahman mh. Eur J Med Chem. 2018 Feb 25;146:260-273. doi: 10.1016/j.ejmech.2018.01.042. Epub 2018 Jan 31. Eur J Med Chem. 2018. PMID: 29407956
175 results