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BRD9 determines the cell fate of hematopoietic stem cells by regulating chromatin state.
Xiao M, Kondo S, Nomura M, Kato S, Nishimura K, Zang W, Zhang Y, Akashi T, Viny A, Shigehiro T, Ikawa T, Yamazaki H, Fukumoto M, Tanaka A, Hayashi Y, Koike Y, Aoyama Y, Ito H, Nishikawa H, Kitamura T, Kanai A, Yokoyama A, Fujiwara T, Goyama S, Noguchi H, Lee SC, Toyoda A, Hinohara K, Abdel-Wahab O, Inoue D. Xiao M, et al. Nat Commun. 2023 Dec 15;14(1):8372. doi: 10.1038/s41467-023-44081-6. Nat Commun. 2023. PMID: 38102116 Free PMC article.
SETBP1 mutations drive leukemic transformation in ASXL1-mutated MDS.
Inoue D, Kitaura J, Matsui H, Hou HA, Chou WC, Nagamachi A, Kawabata KC, Togami K, Nagase R, Horikawa S, Saika M, Micol JB, Hayashi Y, Harada Y, Harada H, Inaba T, Tien HF, Abdel-Wahab O, Kitamura T. Inoue D, et al. Leukemia. 2015 Apr;29(4):847-57. doi: 10.1038/leu.2014.301. Epub 2014 Oct 13. Leukemia. 2015. PMID: 25306901 Free PMC article.
MSI2 is required for maintaining activated myelodysplastic syndrome stem cells.
Taggart J, Ho TC, Amin E, Xu H, Barlowe TS, Perez AR, Durham BH, Tivnan P, Okabe R, Chow A, Vu L, Park SM, Prieto C, Famulare C, Patel M, Lengner CJ, Verma A, Roboz G, Guzman M, Klimek VM, Abdel-Wahab O, Leslie C, Nimer SD, Kharas MG. Taggart J, et al. Nat Commun. 2016 Feb 22;7:10739. doi: 10.1038/ncomms10739. Nat Commun. 2016. PMID: 26898884 Free PMC article.
Therapeutic targeting of splicing in cancer.
Lee SC, Abdel-Wahab O. Lee SC, et al. Nat Med. 2016 Sep 7;22(9):976-86. doi: 10.1038/nm.4165. Nat Med. 2016. PMID: 27603132 Free PMC article. Review.
Modeling CBL activating mutations in vivo.
Lee SC, Abdel-Wahab O. Lee SC, et al. Blood. 2017 Apr 13;129(15):2046-2048. doi: 10.1182/blood-2017-03-770222. Blood. 2017. PMID: 28408421 Free PMC article.
Expression of mutant Asxl1 perturbs hematopoiesis and promotes susceptibility to leukemic transformation.
Nagase R, Inoue D, Pastore A, Fujino T, Hou HA, Yamasaki N, Goyama S, Saika M, Kanai A, Sera Y, Horikawa S, Ota Y, Asada S, Hayashi Y, Kawabata KC, Takeda R, Tien HF, Honda H, Abdel-Wahab O, Kitamura T. Nagase R, et al. J Exp Med. 2018 Jun 4;215(6):1729-1747. doi: 10.1084/jem.20171151. Epub 2018 Apr 11. J Exp Med. 2018. PMID: 29643185 Free PMC article.
349 results