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Rational design of biodegradable sulphonamide candidates treating septicaemia by synergistic dual inhibition of COX-2/PGE2 axis and DHPS enzyme.
El-Dershaby NH, El-Hawash SA, Kassab SE, Dabees HG, Abdel Moneim AE, Abdel Wahab IA, Abd-Alhaseeb MM, El-Miligy MMM. El-Dershaby NH, et al. Among authors: abd alhaseeb mm. J Enzyme Inhib Med Chem. 2022 Dec;37(1):1737-1751. doi: 10.1080/14756366.2022.2086868. J Enzyme Inhib Med Chem. 2022. PMID: 35707920 Free PMC article.
Identification of new 4-(6-oxopyridazin-1-yl)benzenesulfonamides as multi-target anti-inflammatory agents targeting carbonic anhydrase, COX-2 and 5-LOX enzymes: synthesis, biological evaluations and modelling insights.
Badawi WA, Rashed M, Nocentini A, Bonardi A, Abd-Alhaseeb MM, Al-Rashood ST, Veerakanellore GB, Majrashi TA, Elkaeed EB, Elgendy B, Gratteri P, Supuran CT, Eldehna WM, Elagawany M. Badawi WA, et al. Among authors: abd alhaseeb mm. J Enzyme Inhib Med Chem. 2023 Dec;38(1):2201407. doi: 10.1080/14756366.2023.2201407. J Enzyme Inhib Med Chem. 2023. PMID: 37078173 Free PMC article.
4-(5-Amino-pyrazol-1-yl)benzenesulfonamide derivatives as novel multi-target anti-inflammatory agents endowed with inhibitory activity against COX-2, 5-LOX and carbonic anhydrase: Design, synthesis, and biological assessments.
Ragab MA, Eldehna WM, Nocentini A, Bonardi A, Okda HE, Elgendy B, Ibrahim TS, Abd-Alhaseeb MM, Gratteri P, Supuran CT, Al-Karmalawy AA, Elagawany M. Ragab MA, et al. Among authors: abd alhaseeb mm. Eur J Med Chem. 2023 Mar 15;250:115180. doi: 10.1016/j.ejmech.2023.115180. Epub 2023 Feb 3. Eur J Med Chem. 2023. PMID: 36796297
20 results