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Structure of IL-17A in complex with a potent, fully human neutralizing antibody.
Gerhardt S, Abbott WM, Hargreaves D, Pauptit RA, Davies RA, Needham MR, Langham C, Barker W, Aziz A, Snow MJ, Dawson S, Welsh F, Wilkinson T, Vaugan T, Beste G, Bishop S, Popovic B, Rees G, Sleeman M, Tuske SJ, Coales SJ, Hamuro Y, Russell C. Gerhardt S, et al. Among authors: abbott wm. J Mol Biol. 2009 Dec 18;394(5):905-21. doi: 10.1016/j.jmb.2009.10.008. Epub 2009 Oct 14. J Mol Biol. 2009. PMID: 19835883
Cellularly active N-hydroxyurea FEN1 inhibitors block substrate entry to the active site.
Exell JC, Thompson MJ, Finger LD, Shaw SJ, Debreczeni J, Ward TA, McWhirter C, Siöberg CL, Martinez Molina D, Abbott WM, Jones CD, Nissink JW, Durant ST, Grasby JA. Exell JC, et al. Among authors: abbott wm. Nat Chem Biol. 2016 Oct;12(10):815-21. doi: 10.1038/nchembio.2148. Epub 2016 Aug 15. Nat Chem Biol. 2016. PMID: 27526030 Free PMC article.
248 results