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Marketing authorisation of orphan medicines in Europe from 2000 to 2013.
Hofer MP, Hedman H, Mavris M, Koenig F, Vetter T, Posch M, Vamvakas S, Regnstrom J, Aarum S. Hofer MP, et al. Among authors: aarum s. Drug Discov Today. 2018 Feb;23(2):424-433. doi: 10.1016/j.drudis.2017.10.012. Epub 2017 Oct 23. Drug Discov Today. 2018. PMID: 29074441 Free article. Review.
European regulation on orphan medicinal products: 10 years of experience and future perspectives.
Committee for Orphan Medicinal Products and the European Medicines; Westermark K, Holm BB, Söderholm M, Llinares-Garcia J, Rivière F, Aarum S, Butlen-Ducuing F, Tsigkos S, Wilk-Kachlicka A, N'Diamoi C, Borvendég J, Lyons D, Sepodes B, Bloechl-Daum B, Lhoir A, Todorova M, Kkolos I, Kubáčková K, Bosch-Traberg H, Tillmann V, Saano V, Héron E, Elbers R, Siouti M, Eggenhofer J, Salmon P, Clementi M, Krieviņš D, Matulevičiene A, Metz H, Vincenti AC, Voordouw A, Dembowska-Bagińska B, Nunes AC, Saleh FM, Foltánová T, Možina M, Torrent i Farnell J, Beerman B, Mariz S, Evers MP, Greene L, Thorsteinsson S, Gramstad L, Mavris M, Bignami F, Lorence A, Belorgey C. Committee for Orphan Medicinal Products and the European Medicines, et al. Among authors: aarum s. Nat Rev Drug Discov. 2011 May;10(5):341-9. doi: 10.1038/nrd3445. Nat Rev Drug Discov. 2011. PMID: 21532564 Review.
Use of biomarkers in the context of orphan medicines designation in the European Union.
Tsigkos S, Llinares J, Mariz S, Aarum S, Fregonese L, Dembowska-Baginska B, Elbers R, Evers P, Foltanova T, Lhoir A, Corrêa-Nunes A, O'Connor D, Voordouw A, Westermark K, Sepodes B. Tsigkos S, et al. Among authors: aarum s. Orphanet J Rare Dis. 2014 Jan 27;9:13. doi: 10.1186/1750-1172-9-13. Orphanet J Rare Dis. 2014. PMID: 24461084 Free PMC article.
The same annual dose of 292000 IU of vitamin D (cholecalciferol) on either daily or four monthly basis for elderly women: 1-year comparative study of the effects on serum 25(OH)D concentrations and renal function.
Pekkarinen T, Välimäki VV, Aarum S, Turpeinen U, Hämäläinen E, Löyttyniemi E, Välimäki MJ. Pekkarinen T, et al. Among authors: aarum s. Clin Endocrinol (Oxf). 2010 Apr;72(4):455-61. doi: 10.1111/j.1365-2265.2009.03637.x. Epub 2009 May 25. Clin Endocrinol (Oxf). 2010. PMID: 19486025 Clinical Trial.