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Validation of the Asthma Severity Scoring System (ASSESS) in the ALLIANCE Cohort.
Grychtol R, Riemann L, Gaedcke S, Liu B, DeLuca D, Förster R, Maison N, Thiele D, Jakobs N, Bahmer T, Meyer M, Foth S, Weber S, Rietschel E, Rabe KF, Kopp MV, von Mutius E, Dittrich AM, Hansen G; ALLIANCE Study Group as part of the German Center for Lung Research (DZL). Grychtol R, et al. J Allergy Clin Immunol. 2023 Jun;151(6):1525-1535.e4. doi: 10.1016/j.jaci.2023.01.027. Epub 2023 Feb 15. J Allergy Clin Immunol. 2023. PMID: 36804993 Free article.
IgA+ memory B-cells are significantly increased in patients with asthma and small airway dysfunction.
Habener A, Grychtol R, Gaedcke S, DeLuca D, Dittrich AM, Happle C, Abdo M, Watz H, Pedersen F, König IR, Thiele D, Kopp MV, von Mutius E, Bahmer T, Rabe KF, Meyer-Bahlburg A, Hansen G; ALLIANCE Study Group as part of the German Center for Lung Research (DZL); Fuchs O, Roesler B, Welchering N, Kohistani-Greif N, Kurz J, Landgraf-Rauf K, Laubhahn K, Maison N, Liebl C, Schaub B, Ege M, Illi S, Hose A, Zeitlmann E, Berbig M, Marzi C, Schauberger C, Zissler U, Schmidt-Weber C, Ricklefs I, Diekmann G, Liboschik L, Voigt G, Sultansei L, Weckmann M, Nissen G, Kirsten AM, Waschki B, Herzmann C, Biller H, Gaede KI, Bovermann X, Steinmetz A, Husstedt BL, Nitsche C, Veith V, Szewczyk M, Brinkmann F, Malik A, Schwerk N, Dopfer C, Price M, Jirmo AC, Liu B, Calveron MR, Weber S, Foth S, Skevaki C, Renz H, Meyer M, Schildberg T, Rietschel E, van Koningsbruggen-Rietschel S, Alcazar M. Habener A, et al. Eur Respir J. 2022 Nov 3;60(5):2102130. doi: 10.1183/13993003.02130-2021. Print 2022 Nov. Eur Respir J. 2022. PMID: 35595320 Free PMC article.
BACKGROUND: Comprehensive studies investigated the role of T-cells in asthma which led to personalised treatment options targeting severe eosinophilic asthma. ...METHODS: In the All Age Asthma Cohort (ALLIANCE), a subgroup of 154 adult asthma patients and 28 healthy …
BACKGROUND: Comprehensive studies investigated the role of T-cells in asthma which led to personalised treatment options targeting se …
17q21 Variants Disturb Mucosal Host Defense in Childhood Asthma.
Jakwerth CA, Weckmann M, Illi S, Charles H, Zissler UM, Oelsner M, Guerth F, Omony J, Nemani SSP, Grychtol R, Dittrich AM, Skevaki C, Foth S, Weber S, Alejandre Alcazar MA, van Koningsbruggen-Rietschel S, Brock R, Blau S, Hansen G, Bahmer T, Rabe KF, Brinkmann F, Kopp MV, Chaker AM, Schaub B, von Mutius E, Schmidt-Weber CB; ALLIANCE Study Group as part of the German Center for Lung Research. Jakwerth CA, et al. Am J Respir Crit Care Med. 2024 Apr 15;209(8):947-959. doi: 10.1164/rccm.202305-0934OC. Am J Respir Crit Care Med. 2024. PMID: 38064241
Conversely, there was a reduction in IFN type 1 and type 3 expression signatures at the mRNA and protein levels.Conclusions: This study demonstrates a novel disease-driving mechanism induced by the 17q21 risk allele. ...These findings suggest that GSDMB-related airway cell …
Conversely, there was a reduction in IFN type 1 and type 3 expression signatures at the mRNA and protein levels.Conclusions: This study …