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Page 1
Indole-based allosteric inhibitors of HIV-1 integrase.
Patel PA, Kvaratskhelia N, Mansour Y, Antwi J, Feng L, Koneru P, Kobe MJ, Jena N, Shi G, Mohamed MS, Li C, Kessl JJ, Fuchs JR. Patel PA, et al. Bioorg Med Chem Lett. 2016 Oct 1;26(19):4748-4752. doi: 10.1016/j.bmcl.2016.08.037. Epub 2016 Aug 13. Bioorg Med Chem Lett. 2016. PMID: 27568085 Free PMC article.
The Competitive Interplay between Allosteric HIV-1 Integrase Inhibitor BI/D and LEDGF/p75 during the Early Stage of HIV-1 Replication Adversely Affects Inhibitor Potency.
Feng L, Dharmarajan V, Serrao E, Hoyte A, Larue RC, Slaughter A, Sharma A, Plumb MR, Kessl JJ, Fuchs JR, Bushman FD, Engelman AN, Griffin PR, Kvaratskhelia M. Feng L, et al. ACS Chem Biol. 2016 May 20;11(5):1313-21. doi: 10.1021/acschembio.6b00167. Epub 2016 Mar 2. ACS Chem Biol. 2016. PMID: 26910179 Free PMC article.
HIV-1 integrase multimerization as a therapeutic target.
Feng L, Larue RC, Slaughter A, Kessl JJ, Kvaratskhelia M. Feng L, et al. Curr Top Microbiol Immunol. 2015;389:93-119. doi: 10.1007/82_2015_439. Curr Top Microbiol Immunol. 2015. PMID: 25778682 Free PMC article. Review.
A new class of multimerization selective inhibitors of HIV-1 integrase.
Sharma A, Slaughter A, Jena N, Feng L, Kessl JJ, Fadel HJ, Malani N, Male F, Wu L, Poeschla E, Bushman FD, Fuchs JR, Kvaratskhelia M. Sharma A, et al. PLoS Pathog. 2014 May 29;10(5):e1004171. doi: 10.1371/journal.ppat.1004171. eCollection 2014 May. PLoS Pathog. 2014. PMID: 24874515 Free PMC article.