AI080671/AI/NIAID NIH HHS/United States[Grants and Funding] - Search Results

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Subject: AI080671/AI/NIAID NIH HHS/United States[Grants an - PubMed

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Year	Number of Results
2009	2
2010	8
2011	4
2012	2
2013	5
2014	3
2015	1
2024	0

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Toward the discovery of dual inhibitors for botulinum neurotoxin A: concomitant targeting of endocytosis and light chain protease activity.

Seki H, Xue S, Hixon MS, Pellett S, Remes M, Johnson EA, Janda KD. Seki H, et al. Chem Commun (Camb). 2015 Apr 11;51(28):6226-9. doi: 10.1039/c5cc00677e. Chem Commun (Camb). 2015. PMID: 25759983

A platform stratifying a sequestering agent and a pharmacological antagonist as a means to negate botulinum neurotoxicity.

Harris TL, Lowery CA, Hixon MS, Janda KD. Harris TL, et al. ACS Chem Neurosci. 2014 Aug 20;5(8):632-6. doi: 10.1021/cn500135h. Epub 2014 Jul 11. ACS Chem Neurosci. 2014. PMID: 25000171 Free PMC article.

Benzoquinones as inhibitors of botulinum neurotoxin serotype A.

Bremer PT, Hixon MS, Janda KD. Bremer PT, et al. Bioorg Med Chem. 2014 Aug 1;22(15):3971-81. doi: 10.1016/j.bmc.2014.06.004. Epub 2014 Jun 16. Bioorg Med Chem. 2014. PMID: 24984937 Free PMC article.

Synthesis/biological evaluation of hydroxamic acids and their prodrugs as inhibitors for Botulinum neurotoxin A light chain.

Seki H, Pellett S, Silhár P, Stowe GN, Blanco B, Lardy MA, Johnson EA, Janda KD. Seki H, et al. Bioorg Med Chem. 2014 Feb 1;22(3):1208-17. doi: 10.1016/j.bmc.2013.11.053. Epub 2013 Dec 8. Bioorg Med Chem. 2014. PMID: 24360826 Free PMC article.

Scorpion toxins for the reversal of BoNT-induced paralysis.

Lowery CA, Adler M, Borrell A, Janda KD. Lowery CA, et al. Bioorg Med Chem Lett. 2013 Dec 15;23(24):6743-6. doi: 10.1016/j.bmcl.2013.10.029. Epub 2013 Oct 25. Bioorg Med Chem Lett. 2013. PMID: 24252544 Free PMC article.

Targeting botulinum A cellular toxicity: a prodrug approach.

Silhár P, Eubanks LM, Seki H, Pellett S, Javor S, Tepp WH, Johnson EA, Janda KD. Silhár P, et al. J Med Chem. 2013 Oct 24;56(20):7870-9. doi: 10.1021/jm400873n. Epub 2013 Oct 15. J Med Chem. 2013. PMID: 24127873 Free PMC article.

The C-terminus of Botulinum A Protease Has Profound and Unanticipated Kinetic Consequences Upon the Catalytic Cleft.

Silhár P, Lardy MA, Hixon MS, Shoemaker CB, Barbieri JT, Struss AK, Lively JM, Javor S, Janda KD. Silhár P, et al. ACS Med Chem Lett. 2013 Feb 14;4(2):283-287. doi: 10.1021/ml300428s. Epub 2012 Dec 23. ACS Med Chem Lett. 2013. PMID: 23565325 Free PMC article.

Evaluation of adamantane hydroxamates as botulinum neurotoxin inhibitors: synthesis, crystallography, modeling, kinetic and cellular based studies.

Šilhár P, Silvaggi NR, Pellett S, Čapková K, Johnson EA, Allen KN, Janda KD. Šilhár P, et al. Bioorg Med Chem. 2013 Mar 1;21(5):1344-8. doi: 10.1016/j.bmc.2012.12.001. Epub 2012 Dec 20. Bioorg Med Chem. 2013. PMID: 23340139 Free PMC article.

Formulating a new basis for the treatment against botulinum neurotoxin intoxication: 3,4-Diaminopyridine prodrug design and characterization.

Zakhari JS, Kinoyama I, Hixon MS, Di Mola A, Globisch D, Janda KD. Zakhari JS, et al. Bioorg Med Chem. 2011 Nov 1;19(21):6203-9. doi: 10.1016/j.bmc.2011.09.019. Epub 2011 Sep 14. Bioorg Med Chem. 2011. PMID: 21975066 Free PMC article.

Synthesis and evaluation of library of betulin derivatives against the botulinum neurotoxin A protease.

Šilhár P, Alakurtti S, Čapková K, Xiaochuan F, Shoemaker CB, Yli-Kauhaluoma J, Janda KD. Šilhár P, et al. Bioorg Med Chem Lett. 2011 Apr 15;21(8):2229-31. doi: 10.1016/j.bmcl.2011.02.115. Epub 2011 Mar 4. Bioorg Med Chem Lett. 2011. PMID: 21421315 Free PMC article.

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