AG 20206/AG/NIA NIH HHS/United States[Grants and Funding] - Search Results

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Subject: AG 20206/AG/NIA NIH HHS/United States[Grants and - PubMed

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Year	Number of Results
2003	2
2005	1
2006	1
2007	1
2011	1
2013	1
2014	1
2015	2
2024	0

9 results

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γ-Secretase Modulators and APH1 Isoforms Modulate γ-Secretase Cleavage but Not Position of ε-Cleavage of the Amyloid Precursor Protein (APP).

Lessard CB, Cottrell BA, Maruyama H, Suresh S, Golde TE, Koo EH. Lessard CB, et al. PLoS One. 2015 Dec 17;10(12):e0144758. doi: 10.1371/journal.pone.0144758. eCollection 2015. PLoS One. 2015. PMID: 26678856 Free PMC article.

Modulation of Aβ42 in vivo by γ-secretase modulator in primates and humans.

Ling IF, Golde TE, Galasko DR, Koo EH. Ling IF, et al. Alzheimers Res Ther. 2015 Aug 5;7(1):55. doi: 10.1186/s13195-015-0137-y. eCollection 2015. Alzheimers Res Ther. 2015. PMID: 26244059 Free PMC article.

Emerging therapeutics for Alzheimer's disease.

Chiang K, Koo EH. Chiang K, et al. Annu Rev Pharmacol Toxicol. 2014;54:381-405. doi: 10.1146/annurev-pharmtox-011613-135932. Annu Rev Pharmacol Toxicol. 2014. PMID: 24392696 Review.

Steroids as γ-secretase modulators.

Jung JI, Ladd TB, Kukar T, Price AR, Moore BD, Koo EH, Golde TE, Felsenstein KM. Jung JI, et al. FASEB J. 2013 Sep;27(9):3775-85. doi: 10.1096/fj.12-225649. Epub 2013 May 28. FASEB J. 2013. PMID: 23716494 Free PMC article.

Substrate sequence influences γ-secretase modulator activity, role of the transmembrane domain of the amyloid precursor protein.

Sagi SA, Lessard CB, Winden KD, Maruyama H, Koo JC, Weggen S, Kukar TL, Golde TE, Koo EH. Sagi SA, et al. J Biol Chem. 2011 Nov 18;286(46):39794-803. doi: 10.1074/jbc.M111.277228. Epub 2011 Aug 25. J Biol Chem. 2011. PMID: 21868380 Free PMC article.

A multigram chemical synthesis of the gamma-secretase inhibitor LY411575 and its diastereoisomers.

Fauq AH, Simpson K, Maharvi GM, Golde T, Das P. Fauq AH, et al. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6392-5. doi: 10.1016/j.bmcl.2007.07.062. Epub 2007 Aug 30. Bioorg Med Chem Lett. 2007. PMID: 17897827 Free PMC article.

Inhibitors of Rho-kinase modulate amyloid-beta (Abeta) secretion but lack selectivity for Abeta42.

Leuchtenberger S, Kummer MP, Kukar T, Czirr E, Teusch N, Sagi SA, Berdeaux R, Pietrzik CU, Ladd TB, Golde TE, Koo EH, Weggen S. Leuchtenberger S, et al. J Neurochem. 2006 Jan;96(2):355-65. doi: 10.1111/j.1471-4159.2005.03553.x. Epub 2005 Nov 21. J Neurochem. 2006. PMID: 16300630 Free article.

Evidence that nonsteroidal anti-inflammatory drugs decrease amyloid beta 42 production by direct modulation of gamma-secretase activity.

Weggen S, Eriksen JL, Sagi SA, Pietrzik CU, Ozols V, Fauq A, Golde TE, Koo EH. Weggen S, et al. J Biol Chem. 2003 Aug 22;278(34):31831-7. doi: 10.1074/jbc.M303592200. Epub 2003 Jun 12. J Biol Chem. 2003. PMID: 12805356 Free article.

The non-cyclooxygenase targets of non-steroidal anti-inflammatory drugs, lipoxygenases, peroxisome proliferator-activated receptor, inhibitor of kappa B kinase, and NF kappa B, do not reduce amyloid beta 42 production.

Sagi SA, Weggen S, Eriksen J, Golde TE, Koo EH. Sagi SA, et al. J Biol Chem. 2003 Aug 22;278(34):31825-30. doi: 10.1074/jbc.M303588200. Epub 2003 Jun 12. J Biol Chem. 2003. PMID: 12805355 Free article.

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