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Bile Acids Induce Alterations in Mitochondrial Function in Skeletal Muscle Fibers.
Abrigo J, Olguín H, Gutierrez D, Tacchi F, Arrese M, Cabrera D, Valero-Breton M, Elorza AA, Simon F, Cabello-Verrugio C. Abrigo J, et al. Antioxidants (Basel). 2022 Aug 30;11(9):1706. doi: 10.3390/antiox11091706. Antioxidants (Basel). 2022. PMID: 36139784 Free PMC article.
Cholestatic chronic liver disease is characterized by developing sarcopenia and elevated serum levels of bile acids. Sarcopenia is a skeletal muscle disorder with the hallmarks of muscle weakness, muscle mass loss, and muscle strength decline. ...
Cholestatic chronic liver disease is characterized by developing sarcopenia and elevated serum levels of bile acids. Sarcopenia is a …
Sarcopenia Induced by Chronic Liver Disease in Mice Requires the Expression of the Bile Acids Membrane Receptor TGR5.
Abrigo J, Campos F, Gonzalez F, Aguirre F, Gonzalez A, Huerta-Salgado C, Conejeros S, Simon F, Arrese M, Cabrera D, Elorza AA, Cabello-Verrugio C. Abrigo J, et al. Int J Mol Sci. 2020 Oct 25;21(21):7922. doi: 10.3390/ijms21217922. Int J Mol Sci. 2020. PMID: 33113850 Free PMC article.
In the present study, we evaluated the role of TGR5 signaling in the development of sarcopenia using a model of DDC-induced CLD in C57BL6 wild-type (WT) mice and mice deficient in TGR5 expression (TGR5(-/-) mice). ...
In the present study, we evaluated the role of TGR5 signaling in the development of sarcopenia using a model of DDC-induced CLD in C5 …