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2023 2
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Page 1
Arginine dependency is a therapeutically exploitable vulnerability in chronic myeloid leukaemic stem cells.
Rattigan KM, Zarou MM, Brabcova Z, Prasad B, Zerbst D, Sarnello D, Kalkman ER, Ianniciello A, Scott MT, Dunn K, Shokry E, Sumpton D, Copland M, Tardito S, Vande Voorde J, Mussai F, Cheng P, Helgason GV. Rattigan KM, et al. EMBO Rep. 2023 Oct 9;24(10):e56279. doi: 10.15252/embr.202256279. Epub 2023 Jul 25. EMBO Rep. 2023. PMID: 37489735 Free PMC article.
Cancer-associated fibroblasts require proline synthesis by PYCR1 for the deposition of pro-tumorigenic extracellular matrix.
Kay EJ, Paterson K, Riera-Domingo C, Sumpton D, Däbritz JHM, Tardito S, Boldrini C, Hernandez-Fernaud JR, Athineos D, Dhayade S, Stepanova E, Gjerga E, Neilson LJ, Lilla S, Hedley A, Koulouras G, McGregor G, Jamieson C, Johnson RM, Park M, Kirschner K, Miller C, Kamphorst JJ, Loayza-Puch F, Saez-Rodriguez J, Mazzone M, Blyth K, Zagnoni M, Zanivan S. Kay EJ, et al. Nat Metab. 2022 Jun;4(6):693-710. doi: 10.1038/s42255-022-00582-0. Epub 2022 Jun 27. Nat Metab. 2022. PMID: 35760868 Free PMC article.
Regulatory T cell differentiation is controlled by αKG-induced alterations in mitochondrial metabolism and lipid homeostasis.
Matias MI, Yong CS, Foroushani A, Goldsmith C, Mongellaz C, Sezgin E, Levental KR, Talebi A, Perrault J, Rivière A, Dehairs J, Delos O, Bertand-Michel J, Portais JC, Wong M, Marie JC, Kelekar A, Kinet S, Zimmermann VS, Levental I, Yvan-Charvet L, Swinnen JV, Muljo SA, Hernandez-Vargas H, Tardito S, Taylor N, Dardalhon V. Matias MI, et al. Cell Rep. 2021 Nov 2;37(5):109911. doi: 10.1016/j.celrep.2021.109911. Cell Rep. 2021. PMID: 34731632 Free PMC article.
A map of the altered glioma metabolism.
Deshmukh R, Allega MF, Tardito S. Deshmukh R, et al. Trends Mol Med. 2021 Nov;27(11):1045-1059. doi: 10.1016/j.molmed.2021.07.011. Epub 2021 Sep 3. Trends Mol Med. 2021. PMID: 34489164 Review.
An IDH1-vitamin C crosstalk drives human erythroid development by inhibiting pro-oxidant mitochondrial metabolism.
Gonzalez-Menendez P, Romano M, Yan H, Deshmukh R, Papoin J, Oburoglu L, Daumur M, Dumé AS, Phadke I, Mongellaz C, Qu X, Bories PN, Fontenay M, An X, Dardalhon V, Sitbon M, Zimmermann VS, Gallagher PG, Tardito S, Blanc L, Mohandas N, Taylor N, Kinet S. Gonzalez-Menendez P, et al. Cell Rep. 2021 Feb 2;34(5):108723. doi: 10.1016/j.celrep.2021.108723. Cell Rep. 2021. PMID: 33535038 Free PMC article.