Aínsa JA - Search Results

1

Discovery of 3H-pyrrolo[2,3-c]quinolines with activity against Mycobacterium tuberculosis by allosteric inhibition of the glutamate-5-kinase enzyme.

Panciera M, Lence E, Rodríguez Á, Gracia B, Aínsa JA, Marco-Marín C, Rubio V, Duarte Correia CR, González-Bello C. Panciera M, et al. Among authors: ainsa ja. Eur J Med Chem. 2022 Mar 15;232:114206. doi: 10.1016/j.ejmech.2022.114206. Epub 2022 Feb 22. Eur J Med Chem. 2022. PMID: 35219949 Free article.

2

Design, synthesis and inhibitory activity against Mycobacterium tuberculosis thymidine monophosphate kinase of acyclic nucleoside analogues with a distal imidazoquinolinone.

Familiar O, Munier-Lehmann H, Aínsa JA, Camarasa MJ, Pérez-Pérez MJ. Familiar O, et al. Among authors: ainsa ja. Eur J Med Chem. 2010 Dec;45(12):5910-8. doi: 10.1016/j.ejmech.2010.09.056. Epub 2010 Oct 15. Eur J Med Chem. 2010. PMID: 20951473

3

Antimycobacterial evaluation and preliminary phytochemical investigation of selected medicinal plants traditionally used in Mozambique.

Luo X, Pires D, Aínsa JA, Gracia B, Mulhovo S, Duarte A, Anes E, Ferreira MJ. Luo X, et al. Among authors: ainsa ja. J Ethnopharmacol. 2011 Sep 1;137(1):114-20. doi: 10.1016/j.jep.2011.04.062. Epub 2011 May 5. J Ethnopharmacol. 2011. PMID: 21571059

4

A prodrug approach for improving antituberculosis activity of potent Mycobacterium tuberculosis type II dehydroquinase inhibitors.

Tizón L, Otero JM, Prazeres VF, Llamas-Saiz AL, Fox GC, van Raaij MJ, Lamb H, Hawkins AR, Ainsa JA, Castedo L, González-Bello C. Tizón L, et al. Among authors: ainsa ja. J Med Chem. 2011 Sep 8;54(17):6063-84. doi: 10.1021/jm2006063. Epub 2011 Aug 3. J Med Chem. 2011. PMID: 21780742

5

Zanthoxylum capense constituents with antimycobacterial activity against Mycobacterium tuberculosis in vitro and ex vivo within human macrophages.

Luo X, Pires D, Aínsa JA, Gracia B, Duarte N, Mulhovo S, Anes E, Ferreira MJ. Luo X, et al. Among authors: ainsa ja. J Ethnopharmacol. 2013 Mar 7;146(1):417-22. doi: 10.1016/j.jep.2013.01.013. Epub 2013 Jan 18. J Ethnopharmacol. 2013. PMID: 23337743

6

Structure-Activity Relationships of Spectinamide Antituberculosis Agents: A Dissection of Ribosomal Inhibition and Native Efflux Avoidance Contributions.

Liu J, Bruhn DF, Lee RB, Zheng Z, Janusic T, Scherbakov D, Scherman MS, Boshoff HI, Das S, Rakesh, Waidyarachchi SL, Brewer TA, Gracia B, Yang L, Bollinger J, Robertson GT, Meibohm B, Lenaerts AJ, Ainsa J, Böttger EC, Lee RE. Liu J, et al. ACS Infect Dis. 2017 Jan 13;3(1):72-88. doi: 10.1021/acsinfecdis.6b00158. Epub 2016 Nov 11. ACS Infect Dis. 2017. PMID: 28081607 Free PMC article.

7

Discovery of antimicrobial compounds targeting bacterial type FAD synthetases.

Sebastián M, Anoz-Carbonell E, Gracia B, Cossio P, Aínsa JA, Lans I, Medina M. Sebastián M, et al. Among authors: ainsa ja. J Enzyme Inhib Med Chem. 2018 Dec;33(1):241-254. doi: 10.1080/14756366.2017.1411910. J Enzyme Inhib Med Chem. 2018. PMID: 29258359 Free PMC article.

8

Structure Guided Lead Generation toward Nonchiral M. tuberculosis Thymidylate Kinase Inhibitors.

Song L, Merceron R, Gracia B, Quintana AL, Risseeuw MDP, Hulpia F, Cos P, Aínsa JA, Munier-Lehmann H, Savvides SN, Van Calenbergh S. Song L, et al. Among authors: ainsa ja. J Med Chem. 2018 Apr 12;61(7):2753-2775. doi: 10.1021/acs.jmedchem.7b01570. Epub 2018 Mar 15. J Med Chem. 2018. PMID: 29510037

9

Synergy between Circular Bacteriocin AS-48 and Ethambutol against Mycobacterium tuberculosis.

Aguilar-Pérez C, Gracia B, Rodrigues L, Vitoria A, Cebrián R, Deboosère N, Song OR, Brodin P, Maqueda M, Aínsa JA. Aguilar-Pérez C, et al. Among authors: ainsa ja. Antimicrob Agents Chemother. 2018 Aug 27;62(9):e00359-18. doi: 10.1128/AAC.00359-18. Print 2018 Sep. Antimicrob Agents Chemother. 2018. PMID: 29987141 Free PMC article.

10

Boldine-Derived Alkaloids Inhibit the Activity of DNA Topoisomerase I and Growth of Mycobacterium tuberculosis.

García MT, Carreño D, Tirado-Vélez JM, Ferrándiz MJ, Rodrigues L, Gracia B, Amblar M, Ainsa JA, de la Campa AG. García MT, et al. Among authors: ainsa ja. Front Microbiol. 2018 Jul 24;9:1659. doi: 10.3389/fmicb.2018.01659. eCollection 2018. Front Microbiol. 2018. PMID: 30087665 Free PMC article.

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