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Combination therapy with oncolytic virus and T cells or mRNA vaccine amplifies antitumor effects.
Fu R, Qi R, Xiong H, Lei X, Jiang Y, He J, Chen F, Zhang L, Qiu D, Chen Y, Nie M, Guo X, Zhu Y, Zhang J, Yue M, Cao J, Wang G, Que Y, Fang M, Wang Y, Chen Y, Cheng T, Ge S, Zhang J, Yuan Q, Zhang T, Xia N. Fu R, et al. Signal Transduct Target Ther. 2024 May 3;9(1):118. doi: 10.1038/s41392-024-01824-1. Signal Transduct Target Ther. 2024. PMID: 38702343 Free PMC article.
Two antibodies show broad, synergistic neutralization against SARS-CoV-2 variants by inducing conformational change within the RBD.
Sun H, Deng T, Zhang Y, Lin Y, Jiang Y, Jiang Y, Huang Y, Song S, Cui L, Li T, Xiong H, Lan M, Liu L, Li Y, Fang Q, Yu K, Jiang W, Zhou L, Que Y, Zhang T, Yuan Q, Cheng T, Zhang Z, Yu H, Zhang J, Luo W, Li S, Zheng Q, Gu Y, Xia N. Sun H, et al. Protein Cell. 2024 Feb 1;15(2):121-134. doi: 10.1093/procel/pwad040. Protein Cell. 2024. PMID: 37470320 Free PMC article.
Cross-neutralizing antibodies bind a SARS-CoV-2 cryptic site and resist circulating variants.
Li T, Xue W, Zheng Q, Song S, Yang C, Xiong H, Zhang S, Hong M, Zhang Y, Yu H, Zhang Y, Sun H, Huang Y, Deng T, Chi X, Li J, Wang S, Zhou L, Chen T, Wang Y, Cheng T, Zhang T, Yuan Q, Zhao Q, Zhang J, McLellan JS, Zhou ZH, Zhang Z, Li S, Gu Y, Xia N. Li T, et al. Nat Commun. 2021 Sep 27;12(1):5652. doi: 10.1038/s41467-021-25997-3. Nat Commun. 2021. PMID: 34580306 Free PMC article.