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Page 1
A STING antagonist modulating the interaction with STIM1 blocks ER-to-Golgi trafficking and inhibits lupus pathology.
Prabakaran T, Troldborg A, Kumpunya S, Alee I, Marinković E, Windross SJ, Nandakumar R, Narita R, Zhang BC, Carstensen M, Vejvisithsakul P, Marqvorsen MHS, Iversen MB, Holm CK, Østergaard LJ, Pedersen FS, Pisitkun T, Behrendt R, Pisitkun P, Paludan SR. Prabakaran T, et al. EBioMedicine. 2021 Apr;66:103314. doi: 10.1016/j.ebiom.2021.103314. Epub 2021 Apr 2. EBioMedicine. 2021. PMID: 33813142 Free PMC article.
Defects in LC3B2 and ATG4A underlie HSV2 meningitis and reveal a critical role for autophagy in antiviral defense in humans.
Hait AS, Olagnier D, Sancho-Shimizu V, Skipper KA, Helleberg M, Larsen SM, Bodda C, Moldovan LI, Ren F, Brinck Andersen NS, Thomsen MM, Freytag MR, Darmalinggam S, Parkes I, Kadekar DD, Rahbek SH, van der Horst D, Kristensen LS, Eriksson K, Kjems J, Mostowy S, Christiansen M, Mikkelsen JG, Brandt CT, Paludan SR, Mogensen TH. Hait AS, et al. Sci Immunol. 2020 Dec 11;5(54):eabc2691. doi: 10.1126/sciimmunol.abc2691. Sci Immunol. 2020. PMID: 33310865 Free PMC article.
Brain immune cells undergo cGAS/STING-dependent apoptosis during herpes simplex virus type 1 infection to limit type I IFN production.
Reinert LS, Rashidi AS, Tran DN, Katzilieris-Petras G, Hvidt AK, Gohr M, Fruhwürth S, Bodda C, Thomsen MK, Vendelbo MH, Khan AR, Hansen B, Bergström P, Agholme L, Mogensen TH, Christensen MH, Nyengaard JR, Sen GC, Zetterberg H, Verjans GM, Paludan SR. Reinert LS, et al. J Clin Invest. 2021 Jan 4;131(1):e136824. doi: 10.1172/JCI136824. J Clin Invest. 2021. PMID: 32990676 Free PMC article.
STEEP mediates STING ER exit and activation of signaling.
Zhang BC, Nandakumar R, Reinert LS, Huang J, Laustsen A, Gao ZL, Sun CL, Jensen SB, Troldborg A, Assil S, Berthelsen MF, Scavenius C, Zhang Y, Windross SJ, Olagnier D, Prabakaran T, Bodda C, Narita R, Cai Y, Zhang CG, Stenmark H, Doucet CM, Noda T, Guo Z, Goldbach-Mansky R, Hartmann R, Chen ZJ, Enghild JJ, Bak RO, Thomsen MK, Paludan SR. Zhang BC, et al. Nat Immunol. 2020 Aug;21(8):868-879. doi: 10.1038/s41590-020-0730-5. Epub 2020 Jul 20. Nat Immunol. 2020. PMID: 32690950 Free PMC article.
Lysyl-tRNA synthetase produces diadenosine tetraphosphate to curb STING-dependent inflammation.
Guerra J, Valadao AL, Vlachakis D, Polak K, Vila IK, Taffoni C, Prabakaran T, Marriott AS, Kaczmarek R, Houel A, Auzemery B, Déjardin S, Boudinot P, Nawrot B, Jones NJ, Paludan SR, Kossida S, Langevin C, Laguette N. Guerra J, et al. Sci Adv. 2020 May 22;6(21):eaax3333. doi: 10.1126/sciadv.aax3333. eCollection 2020 May. Sci Adv. 2020. PMID: 32494729 Free PMC article.