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Systematic structure modifications of multitarget prostate cancer drug candidate galeterone to produce novel androgen receptor down-regulating agents as an approach to treatment of advanced prostate cancer.
J Med Chem. 2013 Jun 27;56(12):4880-98. doi: 10.1021/jm400048v. Epub 2013 Jun 7.
J Med Chem. 2013.
PMID: 23713567
Free PMC article.
First chemical feature-based pharmacophore modeling of potent retinoidal retinoic acid metabolism blocking agents (RAMBAs): identification of novel RAMBA scaffolds.
Purushottamachar P, Patel JB, Gediya LK, Clement OO, Njar VC.
Purushottamachar P, et al.
Eur J Med Chem. 2012 Jan;47(1):412-23. doi: 10.1016/j.ejmech.2011.11.010. Epub 2011 Nov 17.
Eur J Med Chem. 2012.
PMID: 22130607
Free PMC article.
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