27948/CRUK_/Cancer Research UK/United Kingdom[Grants and Funding] - Search Results

Year	Number of Results
2020	1
2021	4
2022	3
2023	3
2024	0

1

A TGFβ-ECM-integrin signaling axis drives structural reconfiguration of the bile duct to promote polycystic liver disease.

Waddell SH, Yao Y, Olaizola P, Walker A, Jarman EJ, Gournopanos K, Gradinaru A, Christodoulou E, Gautier P, Boerrigter MM, Cadamuro M, Fabris L, Drenth JP, Kendall TJ, Banales JM, Khamseh A, Mill P, Boulter L. Waddell SH, et al. Sci Transl Med. 2023 Sep 13;15(713):eabq5930. doi: 10.1126/scitranslmed.abq5930. Epub 2023 Sep 13. Sci Transl Med. 2023. PMID: 37703354 Free PMC article.

2

NOTCH signalling - a core regulator of bile duct disease?

Martinez Lyons A, Boulter L. Martinez Lyons A, et al. Dis Model Mech. 2023 Sep 1;16(9):dmm050231. doi: 10.1242/dmm.050231. Epub 2023 Aug 22. Dis Model Mech. 2023. PMID: 37605966 Free PMC article. Review.

3

DKK1 drives immune suppressive phenotypes in intrahepatic cholangiocarcinoma and can be targeted with anti-DKK1 therapeutic DKN-01.

Jarman EJ, Horcas-Lopez M, Waddell SH, MacMaster S, Gournopanos K, Soong DYH, Musialik KI, Tsokkou P, Ng ME, Cambridge WA, Wilson DH, Kagey MH, Newman W, Pollard JW, Boulter L. Jarman EJ, et al. Liver Int. 2023 Jan;43(1):208-220. doi: 10.1111/liv.15383. Epub 2022 Sep 15. Liver Int. 2023. PMID: 35924447 Free PMC article.

4

Joining the dots - NEDDylation in cancer cells regulates the tumour environment in cholangiocarcinoma.

Lüdde T, Boulter L. Lüdde T, et al. J Hepatol. 2022 Jul;77(1):12-14. doi: 10.1016/j.jhep.2022.04.018. Epub 2022 Apr 28. J Hepatol. 2022. PMID: 35490843 No abstract available.

5

In Vivo Modeling of Patient Genetic Heterogeneity Identifies New Ways to Target Cholangiocarcinoma.

Younger NT, Wilson ML, Martinez Lyons A, Jarman EJ, Meynert AM, Grimes GR, Gournopanos K, Waddell SH, Tennant PA, Wilson DH, Guest RV, Wigmore SJ, Acosta JC, Kendall TJ, Taylor MS, Sproul D, Mill P, Boulter L. Younger NT, et al. Cancer Res. 2022 Apr 15;82(8):1548-1559. doi: 10.1158/0008-5472.CAN-21-2556. Cancer Res. 2022. PMID: 35074757 Free PMC article.

6

The developmental origins of Notch-driven intrahepatic bile duct disorders.

Martinez Lyons A, Boulter L. Martinez Lyons A, et al. Dis Model Mech. 2021 Sep 1;14(9):dmm048413. doi: 10.1242/dmm.048413. Epub 2021 Sep 22. Dis Model Mech. 2021. PMID: 34549776 Free PMC article.

7

Notch-IGF1 signaling during liver regeneration drives biliary epithelial cell expansion and inhibits hepatocyte differentiation.

Minnis-Lyons SE, Ferreira-González S, Aleksieva N, Man TY, Gadd VL, Williams MJ, Guest RV, Lu WY, Dwyer BJ, Jamieson T, Nixon C, Van Hul N, Lemaigre FP, McCafferty J, Leclercq IA, Sansom OJ, Boulter L, Forbes SJ. Minnis-Lyons SE, et al. Sci Signal. 2021 Jun 22;14(688):eaay9185. doi: 10.1126/scisignal.aay9185. Sci Signal. 2021. PMID: 34158399

8

Build to understand biliary oncogenesis via organoids and FGFR2 fusion proteins.

Boulter L, Ebrahimkhani MR. Boulter L, et al. J Hepatol. 2021 Aug;75(2):262-264. doi: 10.1016/j.jhep.2021.05.006. Epub 2021 May 21. J Hepatol. 2021. PMID: 34029636 Free PMC article. No abstract available.

9

The fibrotic and immune microenvironments as targetable drivers of metastasis.

Boulter L, Bullock E, Mabruk Z, Brunton VG. Boulter L, et al. Br J Cancer. 2021 Jan;124(1):27-36. doi: 10.1038/s41416-020-01172-1. Epub 2020 Nov 26. Br J Cancer. 2021. PMID: 33239677 Free PMC article. Review.

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