JAK-STAT signaling maintains homeostasis in T cells and macrophages.
Fortelny N, Farlik M, Fife V, Gorki AD, Lassnig C, Maurer B, Meissl K, Dolezal M, Boccuni L, Ravi Sundar Jose Geetha A, Akagha MJ, Karjalainen A, Shoebridge S, Farhat A, Mann U, Jain R, Tikoo S, Zila N, Esser-Skala W, Krausgruber T, Sitnik K, Penz T, Hladik A, Suske T, Zahalka S, Senekowitsch M, Barreca D, Halbritter F, Macho-Maschler S, Weninger W, Neubauer HA, Moriggl R, Knapp S, Sexl V, Strobl B, Decker T, Müller M, Bock C.
Fortelny N, et al.
Nat Immunol. 2024 Apr 24. doi: 10.1038/s41590-024-01804-1. Online ahead of print.
Nat Immunol. 2024.
PMID: 38658806
Baseline JAK-STAT signaling was detected in CD8(+) T cells and macrophages of unperturbed mice-but abrogated in the knockouts and in unstimulated immune cells deprived of their normal tissue context. We observed diverse gene-regulatory programs, including effects of STAT2 …
Baseline JAK-STAT signaling was detected in CD8(+) T cells and macrophages of unperturbed mice-but abrogated in the knockouts and in unstimu …