24759/CRUK_/Cancer Research UK/United Kingdom[Grants and Funding] - Search Results

Year	Number of Results
2018	1
2019	2
2020	4
2021	10
2022	4
2023	2
2024	0

1

Novobiocin blocks nucleic acid binding to Polθ and inhibits stimulation of its ATPase activity.

Syed A, Filandr F, Patterson-Fortin J, Bacolla A, Ravindranathan R, Zhou J, McDonald DT, Albuhluli ME, Verway-Cohen A, Newman JA, Tsai MS, Jones DE, Schriemer DC, D'Andrea AD, Tainer JA. Syed A, et al. Nucleic Acids Res. 2023 Oct 13;51(18):9920-9937. doi: 10.1093/nar/gkad727. Nucleic Acids Res. 2023. PMID: 37665033 Free PMC article.

2

Crystal structures and fragment screening of SARS-CoV-2 NSP14 reveal details of exoribonuclease activation and mRNA capping and provide starting points for antiviral drug development.

Imprachim N, Yosaatmadja Y, Newman JA. Imprachim N, et al. Nucleic Acids Res. 2023 Jan 11;51(1):475-487. doi: 10.1093/nar/gkac1207. Nucleic Acids Res. 2023. PMID: 36546776 Free PMC article.

3

Studies on enmetazobactam clarify mechanisms of widely used β-lactamase inhibitors.

Lang PA, Raj R, Tumber A, Lohans CT, Rabe P, Robinson CV, Brem J, Schofield CJ. Lang PA, et al. Proc Natl Acad Sci U S A. 2022 May 3;119(18):e2117310119. doi: 10.1073/pnas.2117310119. Epub 2022 Apr 29. Proc Natl Acad Sci U S A. 2022. PMID: 35486701 Free PMC article.

4

Studies on the Reactions of Biapenem with VIM Metallo β-Lactamases and the Serine β-Lactamase KPC-2.

Lucic A, Malla TR, Calvopiña K, Tooke CL, Brem J, McDonough MA, Spencer J, Schofield CJ. Lucic A, et al. Antibiotics (Basel). 2022 Mar 16;11(3):396. doi: 10.3390/antibiotics11030396. Antibiotics (Basel). 2022. PMID: 35326858 Free PMC article.

5

Characterization of the SARS-CoV-2 ExoN (nsp14ExoN-nsp10) complex: implications for its role in viral genome stability and inhibitor identification.

Baddock HT, Brolih S, Yosaatmadja Y, Ratnaweera M, Bielinski M, Swift LP, Cruz-Migoni A, Fan H, Keown JR, Walker AP, Morris GM, Grimes JM, Fodor E, Schofield CJ, Gileadi O, McHugh PJ. Baddock HT, et al. Nucleic Acids Res. 2022 Feb 22;50(3):1484-1500. doi: 10.1093/nar/gkab1303. Nucleic Acids Res. 2022. PMID: 35037045 Free PMC article.

6

Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors.

Brem J, Panduwawala T, Hansen JU, Hewitt J, Liepins E, Donets P, Espina L, Farley AJM, Shubin K, Campillos GG, Kiuru P, Shishodia S, Krahn D, Leśniak RK, Schmidt Adrian J, Calvopiña K, Turrientes MC, Kavanagh ME, Lubriks D, Hinchliffe P, Langley GW, Aboklaish AF, Eneroth A, Backlund M, Baran AG, Nielsen EI, Speake M, Kuka J, Robinson J, Grinberga S, Robinson L, McDonough MA, Rydzik AM, Leissing TM, Jimenez-Castellanos JC, Avison MB, Da Silva Pinto S, Pannifer AD, Martjuga M, Widlake E, Priede M, Hopkins Navratilova I, Gniadkowski M, Belfrage AK, Brandt P, Yli-Kauhaluoma J, Bacque E, Page MGP, Björkling F, Tyrrell JM, Spencer J, Lang PA, Baranczewski P, Cantón R, McElroy SP, Jones PS, Baquero F, Suna E, Morrison A, Walsh TR, Schofield CJ. Brem J, et al. Nat Chem. 2022 Jan;14(1):15-24. doi: 10.1038/s41557-021-00831-x. Epub 2021 Dec 13. Nat Chem. 2022. PMID: 34903857

7

X-ray free-electron laser studies reveal correlated motion during isopenicillin N synthase catalysis.

Rabe P, Kamps JJAG, Sutherlin KD, Linyard JDS, Aller P, Pham CC, Makita H, Clifton I, McDonough MA, Leissing TM, Shutin D, Lang PA, Butryn A, Brem J, Gul S, Fuller FD, Kim IS, Cheah MH, Fransson T, Bhowmick A, Young ID, O'Riordan L, Brewster AS, Pettinati I, Doyle M, Joti Y, Owada S, Tono K, Batyuk A, Hunter MS, Alonso-Mori R, Bergmann U, Owen RL, Sauter NK, Claridge TDW, Robinson CV, Yachandra VK, Yano J, Kern JF, Orville AM, Schofield CJ. Rabe P, et al. Sci Adv. 2021 Aug 20;7(34):eabh0250. doi: 10.1126/sciadv.abh0250. Print 2021 Aug. Sci Adv. 2021. PMID: 34417180 Free PMC article.

8

Structural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition.

Yosaatmadja Y, Baddock HT, Newman JA, Bielinski M, Gavard AE, Mukhopadhyay SMM, Dannerfjord AA, Schofield CJ, McHugh PJ, Gileadi O. Yosaatmadja Y, et al. Nucleic Acids Res. 2021 Sep 20;49(16):9310-9326. doi: 10.1093/nar/gkab693. Nucleic Acids Res. 2021. PMID: 34387696 Free PMC article.

9

A phosphate binding pocket is a key determinant of exo- versus endo-nucleolytic activity in the SNM1 nuclease family.

Baddock HT, Newman JA, Yosaatmadja Y, Bielinski M, Schofield CJ, Gileadi O, McHugh PJ. Baddock HT, et al. Nucleic Acids Res. 2021 Sep 20;49(16):9294-9309. doi: 10.1093/nar/gkab692. Nucleic Acids Res. 2021. PMID: 34387694 Free PMC article.

10

Structure, mechanism and crystallographic fragment screening of the SARS-CoV-2 NSP13 helicase.

Newman JA, Douangamath A, Yadzani S, Yosaatmadja Y, Aimon A, Brandão-Neto J, Dunnett L, Gorrie-Stone T, Skyner R, Fearon D, Schapira M, von Delft F, Gileadi O. Newman JA, et al. Nat Commun. 2021 Aug 11;12(1):4848. doi: 10.1038/s41467-021-25166-6. Nat Commun. 2021. PMID: 34381037 Free PMC article.

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