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LRIG1 is a gatekeeper to exit from quiescence in adult neural stem cells.
Marqués-Torrejón MÁ, Williams CAC, Southgate B, Alfazema N, Clements MP, Garcia-Diaz C, Blin C, Arranz-Emparan N, Fraser J, Gammoh N, Parrinello S, Pollard SM. Marqués-Torrejón MÁ, et al. Nat Commun. 2021 May 10;12(1):2594. doi: 10.1038/s41467-021-22813-w. Nat Commun. 2021. PMID: 33972529 Free PMC article.
Glioblastomas acquire myeloid-affiliated transcriptional programs via epigenetic immunoediting to elicit immune evasion.
Gangoso E, Southgate B, Bradley L, Rus S, Galvez-Cancino F, McGivern N, Güç E, Kapourani CA, Byron A, Ferguson KM, Alfazema N, Morrison G, Grant V, Blin C, Sou I, Marques-Torrejon MA, Conde L, Parrinello S, Herrero J, Beck S, Brandner S, Brennan PM, Bertone P, Pollard JW, Quezada SA, Sproul D, Frame MC, Serrels A, Pollard SM. Gangoso E, et al. Cell. 2021 Apr 29;184(9):2454-2470.e26. doi: 10.1016/j.cell.2021.03.023. Epub 2021 Apr 14. Cell. 2021. PMID: 33857425 Free PMC article.
The white matter is a pro-differentiative niche for glioblastoma.
Brooks LJ, Clements MP, Burden JJ, Kocher D, Richards L, Devesa SC, Zakka L, Woodberry M, Ellis M, Jaunmuktane Z, Brandner S, Morrison G, Pollard SM, Dirks PB, Marguerat S, Parrinello S. Brooks LJ, et al. Nat Commun. 2021 Apr 12;12(1):2184. doi: 10.1038/s41467-021-22225-w. Nat Commun. 2021. PMID: 33846316 Free PMC article.
Regional identity of human neural stem cells determines oncogenic responses to histone H3.3 mutants.
Bressan RB, Southgate B, Ferguson KM, Blin C, Grant V, Alfazema N, Wills JC, Marques-Torrejon MA, Morrison GM, Ashmore J, Robertson F, Williams CAC, Bradley L, von Kriegsheim A, Anderson RA, Tomlinson SR, Pollard SM. Bressan RB, et al. Cell Stem Cell. 2021 May 6;28(5):877-893.e9. doi: 10.1016/j.stem.2021.01.016. Epub 2021 Feb 24. Cell Stem Cell. 2021. PMID: 33631116 Free PMC article.