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ADAM17 targeting by human cytomegalovirus remodels the cell surface proteome to simultaneously regulate multiple immune pathways.
Rubina A, Patel M, Nightingale K, Potts M, Fielding CA, Kollnberger S, Lau B, Ladell K, Miners KL, Nichols J, Nobre L, Roberts D, Trinca TM, Twohig JP, Vlahava VM, Davison AJ, Price DA, Tomasec P, Wilkinson GWG, Weekes MP, Stanton RJ, Wang ECY. Rubina A, et al. Proc Natl Acad Sci U S A. 2023 Aug 15;120(33):e2303155120. doi: 10.1073/pnas.2303155120. Epub 2023 Aug 10. Proc Natl Acad Sci U S A. 2023. PMID: 37561786 Free PMC article.
IFITM3 restricts virus-induced inflammatory cytokine production by limiting Nogo-B mediated TLR responses.
Clement M, Forbester JL, Marsden M, Sabberwal P, Sommerville MS, Wellington D, Dimonte S, Clare S, Harcourt K, Yin Z, Nobre L, Antrobus R, Jin B, Chen M, Makvandi-Nejad S, Lindborg JA, Strittmatter SM, Weekes MP, Stanton RJ, Dong T, Humphreys IR. Clement M, et al. Nat Commun. 2022 Sep 8;13(1):5294. doi: 10.1038/s41467-022-32587-4. Nat Commun. 2022. PMID: 36075894 Free PMC article.
SARS-CoV-2 host-shutoff impacts innate NK cell functions, but antibody-dependent NK activity is strongly activated through non-spike antibodies.
Fielding CA, Sabberwal P, Williamson JC, Greenwood EJD, Crozier TWM, Zelek W, Seow J, Graham C, Huettner I, Edgeworth JD, Price DA, Morgan PB, Ladell K, Eberl M, Humphreys IR, Merrick B, Doores K, Wilson SJ, Lehner PJ, Wang ECY, Stanton RJ. Fielding CA, et al. Elife. 2022 May 19;11:e74489. doi: 10.7554/eLife.74489. Elife. 2022. PMID: 35587364 Free PMC article.
An Analysis of Serological Response and Infection Outcomes Following Oxford-AstraZeneca (AZD1222) and Pfizer-BioNTech (mRNA BNT162b2) SARS-CoV-2 Vaccines in Kidney and Kidney-pancreas Transplants.
Asderakis A, Khalid U, Koimtzis G, Ponsford MJ, Szabo L, Chalklin C, Bramhall K, Grant L, Moat SJ, Humphreys IR, Jolles SR. Asderakis A, et al. Transplantation. 2022 Jul 1;106(7):1421-1429. doi: 10.1097/TP.0000000000004105. Epub 2022 Mar 8. Transplantation. 2022. PMID: 35283457 Free PMC article.
26 results