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Phosphorylation-regulated phase separation of syndecan-4 and syntenin promotes the biogenesis of exosomes.
Zhao T, Yang X, Duan G, Chen J, He K, Chen YX, Luo SZ. Zhao T, et al. Cell Prolif. 2024 Apr 11:e13645. doi: 10.1111/cpr.13645. Online ahead of print. Cell Prolif. 2024. PMID: 38601993
The interaction between the transmembrane protein syndecan-4 (SDC4) and cytosolic protein syntenin plays a key role in the biogenesis of exosomes. However, how the relatively weak binding of syntenin to SDC4 efficiently enables syntenin sorting for packaging into exosomes …
The interaction between the transmembrane protein syndecan-4 (SDC4) and cytosolic protein syntenin plays a key role in the biogenesis …
Recent Advances in Post-polymerization Modifications on Polypeptides: Synthesis and Applications.
Li Y, Chang R, Chen YX. Li Y, et al. Chem Asian J. 2022 Jul 15;17(14):e202200318. doi: 10.1002/asia.202200318. Epub 2022 May 31. Chem Asian J. 2022. PMID: 35576055 Review.
To synthesize polypeptides with desired functions, post-polymerization modification (PPM) plays an important role in introducing novel chemical structure on their side-chains. The key to PPM strategy is to develop highly selective and efficient reactions that can couple th …
To synthesize polypeptides with desired functions, post-polymerization modification (PPM) plays an important role in introducing novel chemi …