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Altered amyloid-β structure markedly reduces gliosis in the brain of mice harboring the Uppsala APP deletion.
Pagnon de la Vega M, Syvänen S, Giedraitis V, Hooley M, Konstantinidis E, Meier SR, Rokka J, Eriksson J, Aguilar X, Spires-Jones TL, Lannfelt L, Nilsson LNG, Erlandsson A, Hultqvist G, Ingelsson M, Sehlin D. Pagnon de la Vega M, et al. Acta Neuropathol Commun. 2024 Feb 5;12(1):22. doi: 10.1186/s40478-024-01734-x. Acta Neuropathol Commun. 2024. PMID: 38317196 Free PMC article.
Cryo-EM of Aβ fibrils from mouse models find tg-APPArcSwe fibrils resemble those found in patients with sporadic Alzheimer's disease.
Zielinski M, Peralta Reyes FS, Gremer L, Schemmert S, Frieg B, Schäfer LU, Willuweit A, Donner L, Elvers M, Nilsson LNG, Syvänen S, Sehlin D, Ingelsson M, Willbold D, Schröder GF. Zielinski M, et al. Nat Neurosci. 2023 Dec;26(12):2073-2080. doi: 10.1038/s41593-023-01484-4. Epub 2023 Nov 16. Nat Neurosci. 2023. PMID: 37973869 Free PMC article.
PET Imaging in Preclinical Anti-Aβ Drug Development.
Syvänen S, Meier SR, Roshanbin S, Xiong M, Faresjö R, Gustavsson T, Bonvicini G, Schlein E, Aguilar X, Julku U, Eriksson J, Sehlin D. Syvänen S, et al. Pharm Res. 2022 Jul;39(7):1481-1496. doi: 10.1007/s11095-022-03277-z. Epub 2022 May 2. Pharm Res. 2022. PMID: 35501533 Free PMC article. Review.