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IFIH1 was predicted as a key biomarker in primary Sjogren's syndrome based on transcriptome analysis and experimental verification in patients and mice.
Wu D, Chen L, Wang D, Wang Y, Yao G, Sun L. Wu D, et al. Int J Rheum Dis. 2023 May;26(5):895-906. doi: 10.1111/1756-185X.14668. Epub 2023 Mar 27. Int J Rheum Dis. 2023. PMID: 36973184
OBJECTIVES: To investigate the novel key genes and biological processes that may lead to primary Sjogren' s syndrome (pSS). ...Lastly, the expression of key genes was verified in pSS patients and murine models by reverse-transcription polymerase chain reaction. ...
OBJECTIVES: To investigate the novel key genes and biological processes that may lead to primary Sjogren' s syndrome (pSS). ...Lastly …
Prediction of diagnosis results of rheumatoid arthritis patients based on autoantibodies and cost-sensitive neural network.
Geng L, Qu W, Wang S, Chen J, Xu Y, Kong W, Xu X, Feng X, Zhao C, Liang J, Zhang H, Sun L. Geng L, et al. Clin Rheumatol. 2022 Aug;41(8):2329-2339. doi: 10.1007/s10067-022-06109-y. Epub 2022 Apr 11. Clin Rheumatol. 2022. PMID: 35404026
CONCLUSION: In-depth analysis of autoantibodies and reliable early diagnosis based on the neural network could guide specialized physicians to develop different treatment plans to prevent deterioration and enable early treatment with antirheumatic drugs for remission. Key
CONCLUSION: In-depth analysis of autoantibodies and reliable early diagnosis based on the neural network could guide specialized physicians …
Coexpression network analysis coupled with connectivity map database mining reveals novel genetic biomarkers and potential therapeutic drugs for polymyositis.
Wang K, Zhu R, Li J, Zhang Z, Wen X, Chen H, Sun L. Wang K, et al. Clin Rheumatol. 2022 Jun;41(6):1719-1730. doi: 10.1007/s10067-021-06035-5. Epub 2022 Jan 29. Clin Rheumatol. 2022. PMID: 35091780
CONCLUSIONS: We used WGCNA to observe all aspects of PM, which helped to elucidate the molecular mechanisms of PM onset and progression and provide candidate targets for the diagnosis and treatment of PM. Key Points Four microarray datasets were analysed in patients with p …
CONCLUSIONS: We used WGCNA to observe all aspects of PM, which helped to elucidate the molecular mechanisms of PM onset and progression and …