Abstract
This paper describes a synthesis of ALC-0315 by a sequence that more than doubles the overall yield relative to the published one, and that employs much cleaner reactions, thereby facilitating purifications to a considerable extent.
Keywords:
RNA therapeutics; lipids; reductive amination; vaccines.
© 2022 Wiley-VCH GmbH.
MeSH terms
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Amination
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Amino Alcohols
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COVID-19 Vaccines*
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COVID-19* / prevention & control
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Decanoates
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Humans
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Lipids
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Oxidation-Reduction
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Vaccines, Synthetic
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mRNA Vaccines
Substances
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Amino Alcohols
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COVID-19 Vaccines
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Decanoates
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Lipids
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Vaccines, Synthetic
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mRNA Vaccines
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(4-hydroxybutyl)azanediyl)bis(hexane-6,1-diyl)bis(2-hexyldecanoate)