Lower oxygen consumption and Complex I activity in mitochondria isolated from skeletal muscle of fetal sheep with intrauterine growth restriction.
Pendleton AL, Antolic AT, Kelly AC, Davis MA, Camacho LE, Doubleday K, Anderson MJ, Langlais PR, Lynch RM, Limesand SW.
Pendleton AL, et al.
Am J Physiol Endocrinol Metab. 2020 Jul 1;319(1):E67-E80. doi: 10.1152/ajpendo.00057.2020. Epub 2020 May 12.
Am J Physiol Endocrinol Metab. 2020.
PMID: 32396498
Free PMC article.
At 132 1 days of gestation, biceps femoris muscles were collected, and the mitochondria were isolated. Mitochondria from IUGR muscle have 47% lower State 3 (Complex I-dependent) OCRs than controls, whereas State 4 (proton leak) OCRs were not different between groups …
At 132 1 days of gestation, biceps femoris muscles were collected, and the mitochondria were isolated. Mitochondria from IUGR muscle have 47 …