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Targeting vulnerable microcircuits in the ventral hippocampus of male transgenic mice to rescue Alzheimer-like social memory loss.
Lei HY, Pi GL, He T, Xiong R, Lv JR, Liu JL, Wu DQ, Li MZ, Shi K, Li SH, Yu NN, Gao Y, Yu HL, Wei LY, Wang X, Zhou QZ, Zou PL, Zhou JY, Liu YZ, Shen NT, Yang J, Ke D, Wang Q, Liu GP, Yang XF, Wang JZ, Yang Y. Lei HY, et al. Mil Med Res. 2024 Mar 11;11(1):16. doi: 10.1186/s40779-024-00512-z. Mil Med Res. 2024. PMID: 38462603 Free PMC article.
BACKGROUND: Episodic memory loss is a prominent clinical manifestation of Alzheimer's disease (AD), which is closely related to tau pathology and hippocampal impairment. ...
BACKGROUND: Episodic memory loss is a prominent clinical manifestation of Alzheimer's disease (AD), which is closely related to tau p …
A blood-based multi-pathway biomarker assay for early detection and staging of Alzheimer's disease across ethnic groups.
Jiang Y, Uhm H, Ip FC, Ouyang L, Lo RMN, Cheng EYL, Cao X, Tan CMC, Law BCH, Ortiz-Romero P, Puig-Pijoan A, Fernández-Lebrero A, Contador J, Mok KY, Hardy J, Kwok TCY, Mok VCT, Suárez-Calvet M, Zetterberg H, Fu AKY, Ip NY. Jiang Y, et al. Alzheimers Dement. 2024 Mar;20(3):2000-2015. doi: 10.1002/alz.13676. Epub 2024 Jan 6. Alzheimers Dement. 2024. PMID: 38183344 Free PMC article.
INTRODUCTION: Existing blood-based biomarkers for Alzheimer's disease (AD) mainly focus on its pathological features. However, studies on blood-based biomarkers associated with other biological processes for a comprehensive evaluation of AD status are limited. ...HIGHLIGHT …
INTRODUCTION: Existing blood-based biomarkers for Alzheimer's disease (AD) mainly focus on its pathological features. However, studie …
Brain amyloid-β deposition associated functional connectivity changes of ultra-large structural scale in mild cognitive impairment.
Cui L, Zhang Z, Huang YL, Xie F, Guan YH, Lo CZ, Guo YH, Jiang JH, Guo QH. Cui L, et al. Brain Imaging Behav. 2023 Oct;17(5):494-506. doi: 10.1007/s11682-023-00780-8. Epub 2023 May 16. Brain Imaging Behav. 2023. PMID: 37188840
In preclinical Alzheimer's disease, neuro-functional changes due to amyloid-beta (Abeta) deposition are not synchronized in different brain lobes and subcortical nuclei. ...
In preclinical Alzheimer's disease, neuro-functional changes due to amyloid-beta (Abeta) deposition are not synchronized in different …
Inhibiting NLRP3 Inflammasome Activation by CY-09 Helps to Restore Cerebral Glucose Metabolism in 3×Tg-AD Mice.
Han S, He Z, Hu X, Li X, Zheng K, Huang Y, Xiao P, Xie Q, Ni J, Liu Q. Han S, et al. Antioxidants (Basel). 2023 Mar 15;12(3):722. doi: 10.3390/antiox12030722. Antioxidants (Basel). 2023. PMID: 36978970 Free PMC article.
The reduction of the cerebral glucose metabolism is closely related to the activation of the NOD-like receptor protein 3 (NLRP3) inflammasome in Alzheimer's disease (AD); however, its underlying mechanism remains unclear. ...
The reduction of the cerebral glucose metabolism is closely related to the activation of the NOD-like receptor protein 3 (NLRP3) inflammasom …
Study of Diet Habits and Cognitive Function in the Chinese Middle-Aged and Elderly Population: The Association between Folic Acid, B Vitamins, Vitamin D, Coenzyme Q10 Supplementation and Cognitive Ability.
Jiang X, Guo Y, Cui L, Huang L, Guo Q, Huang G. Jiang X, et al. Nutrients. 2023 Mar 1;15(5):1243. doi: 10.3390/nu15051243. Nutrients. 2023. PMID: 36904242 Free PMC article.
The sample consisted of 892 adults aged above 50 who were assessed for their cognitive status in the Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine (China) from July 2019 to January 2022. According to the degree of cognitive …
The sample consisted of 892 adults aged above 50 who were assessed for their cognitive status in the Shanghai Sixth People's Hospital …
The association of subjective sleep characteristics and plasma biomarkers of Alzheimer's disease pathology in older cognitively unimpaired adults with higher amyloid-beta burden.
Chu H, Huang C, Miao Y, Ren C, Guan Y, Xie F, Fang Z, Guo Q. Chu H, et al. J Neurol. 2023 Jun;270(6):3008-3021. doi: 10.1007/s00415-023-11626-0. Epub 2023 Feb 20. J Neurol. 2023. PMID: 36806992
We aimed to investigate the association of subjective sleep characteristics and plasma Alzheimer's disease (AD) biomarkers in older cognitively unimpaired adults with higher amyloid-beta (Abeta) burden. ...
We aimed to investigate the association of subjective sleep characteristics and plasma Alzheimer's disease (AD) biomarkers in older c …
The Central Nervous Mechanism of Stress-Promoting Cancer Progression.
Hong Y, Zhang L, Liu N, Xu X, Liu D, Tu J. Hong Y, et al. Int J Mol Sci. 2022 Oct 21;23(20):12653. doi: 10.3390/ijms232012653. Int J Mol Sci. 2022. PMID: 36293510 Free PMC article. Review.
In recent years, many studies have shown that stress-related hormones or peripheral neurotransmitters can promote the proliferation, survival, and angiogenesis of tumor cells and impair the body's immune response, causing tumor cells to escape the "surveillance" of the imm …
In recent years, many studies have shown that stress-related hormones or peripheral neurotransmitters can promote the proliferation, surviva …
17 results