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HWL-088, a new and highly effective FFA1/PPARδ dual agonist, attenuates nonalcoholic steatohepatitis by regulating lipid metabolism, inflammation and fibrosis.
Hu L, Zhou Z, Deng L, Ren Q, Cai Z, Wang B, Li Z, Wang G. Hu L, et al. J Pharm Pharmacol. 2020 Nov;72(11):1564-1573. doi: 10.1111/jphp.13342. Epub 2020 Jul 31. J Pharm Pharmacol. 2020. PMID: 32734608
METHODS: The methionine- and choline-deficient diet (MCD)-induced Nonalcoholic steatohepatitis (NASH) model was constructed to evaluate the effects of HWL-088. KEY FINDINGS: Administration of HWL-088 exerted multiple benefits on glucose control, lipid metabolism and fatty …
METHODS: The methionine- and choline-deficient diet (MCD)-induced Nonalcoholic steatohepatitis (NASH) model was constructed to evaluate the …