Pharmacokinetics and brain distribution studies of 6-hydroxykynurenic acid and its structural modified compounds.
Shen Z, Hu H, Pan J, Xu M, Ou F, He K, Zeng K, Yao J, Wang R, Lou Y, Zeng S.
Shen Z, et al.
J Pharm Pharmacol. 2022 Jan 5;74(1):22-31. doi: 10.1093/jpp/rgab132.
J Pharm Pharmacol. 2022.
PMID: 34586411
The methods were effectively applied to investigate the effects of structural modification on apparent permeability coefficients in cells, the pharmacokinetics and the brain distribution in rats. KEY FINDINGS: The results illustrated that esterification can greatly improve …
The methods were effectively applied to investigate the effects of structural modification on apparent permeability coefficients in cells, t …