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Increased alpha-synuclein and neuroinflammation in the substantia nigra triggered by systemic inflammation are reversed by targeted inhibition of the receptor for advanced glycation end products (RAGE).
Peixoto DO, Bittencourt RR, Gasparotto J, Kessler FGC, Brum PO, Somensi N, Girardi CS, Dos Santos da Silva L, Outeiro TF, Moreira JCF, Gelain DP. Peixoto DO, et al. J Neurochem. 2023 Sep 3. doi: 10.1111/jnc.15956. Online ahead of print. J Neurochem. 2023. PMID: 37661637
Considering the role of this receptor in the initiation and establishment of neuroinflammation, and the limited understanding of the function of RAGE in the maintenance of this condition, this study describes the effects of RAGE inhibition in the brain, through an intranas …
Considering the role of this receptor in the initiation and establishment of neuroinflammation, and the limited understanding of the functio …
Mancozeb exposure results in manganese accumulation and Nrf2-related antioxidant responses in the brain of common carp Cyprinus carpio.
Costa-Silva DG, Lopes AR, Martins IK, Leandro LP, Nunes MEM, de Carvalho NR, Rodrigues NR, Macedo GE, Saidelles AP, Aguiar C, Doneda M, Flores EMM, Posser T, Franco JL. Costa-Silva DG, et al. Environ Sci Pollut Res Int. 2018 Jun;25(16):15529-15540. doi: 10.1007/s11356-018-1724-9. Epub 2018 Mar 22. Environ Sci Pollut Res Int. 2018. PMID: 29569203
Manganese (Mn)-containing dithiocarbamates such as Mancozeb (MZ) have been shown to induce oxidative stress-related toxicity in rodents and humans. However, little is known about the neurotoxic effects induced by MZ in fish. In this study, carp (Cyprinus carpio) were expos …
Manganese (Mn)-containing dithiocarbamates such as Mancozeb (MZ) have been shown to induce oxidative stress-related toxicity in rodents and …