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De novo phosphatidylcholine synthesis in the small intestinal epithelium is required for normal dietary lipid handling and maintenance of the mucosal barrier.
Biochim Biophys Acta Mol Cell Biol Lipids. 2022 Apr;1867(4):159109. doi: 10.1016/j.bbalip.2021.159109. Epub 2022 Jan 7.
Biochim Biophys Acta Mol Cell Biol Lipids. 2022.
PMID: 35007755
Intestinal Phospholipid Disequilibrium Initiates an ER Stress Response That Drives Goblet Cell Necroptosis and Spontaneous Colitis in Mice.
Kennelly JP, Carlin S, Ju T, van der Veen JN, Nelson RC, Buteau J, Thiesen A, Richard C, Willing BP, Jacobs RL.
Kennelly JP, et al.
Cell Mol Gastroenterol Hepatol. 2021;11(4):999-1021. doi: 10.1016/j.jcmgh.2020.11.006. Epub 2020 Nov 22.
Cell Mol Gastroenterol Hepatol. 2021.
PMID: 33238221
Free PMC article.
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The marine compound and elongation factor 1A1 inhibitor, didemnin B, provides benefit in western diet-induced non-alcoholic fatty liver disease.
Wilson RB, Chen YJ, Sutherland BG, Sawyez CG, Zhang R, Woolnough T, Hetherington AM, Peters KM, Patel K, Kennelly JP, Leonard KA, Schuurman M, Jacobs RL, Wang R, Borradaile NM.
Wilson RB, et al.
Pharmacol Res. 2020 Nov;161:105208. doi: 10.1016/j.phrs.2020.105208. Epub 2020 Sep 22.
Pharmacol Res. 2020.
PMID: 32977024
Free article.
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Intestinal de novo phosphatidylcholine synthesis is required for dietary lipid absorption and metabolic homeostasis.
Kennelly JP, van der Veen JN, Nelson RC, Leonard KA, Havinga R, Buteau J, Kuipers F, Jacobs RL.
Kennelly JP, et al.
J Lipid Res. 2018 Sep;59(9):1695-1708. doi: 10.1194/jlr.M087056. Epub 2018 Jul 14.
J Lipid Res. 2018.
PMID: 30007917
Free PMC article.
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