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The Trypanosoma brucei MISP family of invariant proteins is co-expressed with BARP as triple helical bundle structures on the surface of salivary gland forms, but is dispensable for parasite development within the tsetse vector.
Casas-Sanchez A, Ramaswamy R, Perally S, Haines LR, Rose C, Aguilera-Flores M, Portillo S, Verbeelen M, Hussain S, Smithson L, Yunta C, Lehane MJ, Vaughan S, van den Abbeele J, Almeida IC, Boulanger MJ, Acosta-Serrano Á. Casas-Sanchez A, et al. PLoS Pathog. 2023 Mar 30;19(3):e1011269. doi: 10.1371/journal.ppat.1011269. eCollection 2023 Mar. PLoS Pathog. 2023. PMID: 36996244 Free PMC article.
Repurposing the orphan drug nitisinone to control the transmission of African trypanosomiasis.
Sterkel M, Haines LR, Casas-Sánchez A, Owino Adung'a V, Vionette-Amaral RJ, Quek S, Rose C, Silva Dos Santos M, García Escude N, Ismail HM, Paine MI, Barribeau SM, Wagstaff S, MacRae JI, Masiga D, Yakob L, Oliveira PL, Acosta-Serrano Á. Sterkel M, et al. PLoS Biol. 2021 Jan 26;19(1):e3000796. doi: 10.1371/journal.pbio.3000796. eCollection 2021 Jan. PLoS Biol. 2021. PMID: 33497373 Free PMC article.
Pneumococcal colonization impairs mucosal immune responses to live attenuated influenza vaccine.
Carniel BF, Marcon F, Rylance J, German EL, Zaidi S, Reiné J, Negera E, Nikolaou E, Pojar S, Solórzano C, Collins AM, Connor V, Bogaert D, Gordon SB, Nakaya HI, Ferreira DM, Jochems SP, Mitsi E. Carniel BF, et al. JCI Insight. 2021 Feb 22;6(4):e141088. doi: 10.1172/jci.insight.141088. JCI Insight. 2021. PMID: 33497364 Free PMC article. Clinical Trial.
Experimental Human Challenge Defines Distinct Pneumococcal Kinetic Profiles and Mucosal Responses between Colonized and Non-Colonized Adults.
Nikolaou E, Jochems SP, Mitsi E, Pojar S, Blizard A, Reiné J, Solórzano C, Negera E, Carniel B, Soares-Schanoski A, Connor V, Adler H, Zaidi SR, Hales C, Hill H, Hyder-Wright A, Gordon SB, Rylance J, Ferreira DM. Nikolaou E, et al. mBio. 2021 Jan 12;12(1):e02020-20. doi: 10.1128/mBio.02020-20. mBio. 2021. PMID: 33436429 Free PMC article.
Nasal Pneumococcal Density Is Associated with Microaspiration and Heightened Human Alveolar Macrophage Responsiveness to Bacterial Pathogens.
Mitsi E, Carniel B, Reiné J, Rylance J, Zaidi S, Soares-Schanoski A, Connor V, Collins AM, Schlitzer A, Nikolaou E, Solórzano C, Pojar S, Hill H, Hyder-Wright AD, Jambo KC, Oggioni MR, De Ste Croix M, Gordon SB, Jochems SP, Ferreira DM. Mitsi E, et al. Am J Respir Crit Care Med. 2020 Feb 1;201(3):335-347. doi: 10.1164/rccm.201903-0607OC. Am J Respir Crit Care Med. 2020. PMID: 31626559 Free PMC article.
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