Design of Mn porphyrins for treating oxidative stress injuries and their redox-based regulation of cellular transcriptional activities.
Batinic-Haberle I, Spasojevic I, Tse HM, Tovmasyan A, Rajic Z, St Clair DK, Vujaskovic Z, Dewhirst MW, Piganelli JD.
Batinic-Haberle I, et al.
Amino Acids. 2012 Jan;42(1):95-113. doi: 10.1007/s00726-010-0603-6. Epub 2010 May 16.
Amino Acids. 2012.
PMID: 20473774
Free PMC article.
Review.
We have reported on the inhibition of major transcription factors HIF-1alpha, AP-1, SP-1, and NF-kappaB by Mn porphyrins. While the prevailing mechanistic view of the suppression of transcription factors activation is via antioxidative action (presumably in cytosol) …
We have reported on the inhibition of major transcription factors HIF-1alpha, AP-1, SP-1, and NF-kappaB by Mn porphyrins. Whil …