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Biochemical and structural characterization of lysophosphatidic Acid binding by a humanized monoclonal antibody.
Fleming JK, Wojciak JM, Campbell MA, Huxford T. Fleming JK, et al. J Mol Biol. 2011 May 6;408(3):462-76. doi: 10.1016/j.jmb.2011.02.061. Epub 2011 Mar 15. J Mol Biol. 2011. PMID: 21392506 Free PMC article.
We have determined the X-ray crystal structure of an anti-LPA antibody (LT3015) Fab fragment in its antigen-free form to 2.15 A resolution and in complex with two LPA isotypes (14:0 and 18:2) to resolutions of 1.98 and 2.51 A, respectively. The variable CDR (complementarit …
We have determined the X-ray crystal structure of an anti-LPA antibody (LT3015) Fab fragment in its antigen-free form to 2.15 A resolution a …
The crystal structure of sphingosine-1-phosphate in complex with a Fab fragment reveals metal bridging of an antibody and its antigen.
Wojciak JM, Zhu N, Schuerenberg KT, Moreno K, Shestowsky WS, Hiraiwa M, Sabbadini R, Huxford T. Wojciak JM, et al. Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17717-22. doi: 10.1073/pnas.0906153106. Epub 2009 Oct 7. Proc Natl Acad Sci U S A. 2009. PMID: 19815502 Free PMC article.
The pleiotropic signaling lipid sphingosine-1-phosphate (S1P) plays significant roles in angiogenesis, heart disease, and cancer. ...The amino alcohol head group of the sphingosine backbone is recognized through hydrogen bonding interactions from 1 aa side chain and …
The pleiotropic signaling lipid sphingosine-1-phosphate (S1P) plays significant roles in angiogenesis, heart disease, and cancer. ... …