Hepatic drug-metabolizing enzymes and drug transporters in Wilson's disease patients with liver failure.
Szeląg-Pieniek S, Oswald S, Post M, Łapczuk-Romańska J, Droździk M, Kurzawski M.
Szeląg-Pieniek S, et al.
Pharmacol Rep. 2021 Oct;73(5):1427-1438. doi: 10.1007/s43440-021-00290-8. Epub 2021 Jun 11.
Pharmacol Rep. 2021.
PMID: 34117631
Free PMC article.
As for ABC transporters, the protein abundance of BSEP and MRP2 was significantly lower, while levels of P-gp and MRP4 transporters were significantly higher in Wilson's disease. CONCLUSIONS: Altered hepatic expression of drug-metabolizing enzymes and drug transporters in …
As for ABC transporters, the protein abundance of BSEP and MRP2 was significantly lower, while levels of P-gp and MRP4 transporters were sig …