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Page 1
Single-cell profiling of environmental enteropathy reveals signatures of epithelial remodeling and immune activation.
Kummerlowe C, Mwakamui S, Hughes TK, Mulugeta N, Mudenda V, Besa E, Zyambo K, Shay JES, Fleming I, Vukovic M, Doran BA, Aicher TP, Wadsworth MH 2nd, Bramante JT, Uchida AM, Fardoos R, Asowata OE, Herbert N, Yilmaz ÖH, Kløverpris HN, Garber JJ, Ordovas-Montañes J, Gartner ZJ, Wallach T, Shalek AK, Kelly P. Kummerlowe C, et al. Sci Transl Med. 2022 Aug 31;14(660):eabi8633. doi: 10.1126/scitranslmed.abi8633. Epub 2022 Aug 31. Sci Transl Med. 2022. PMID: 36044598 Free PMC article.
Desmosterol suppresses macrophage inflammasome activation and protects against vascular inflammation and atherosclerosis.
Zhang X, McDonald JG, Aryal B, Canfrán-Duque A, Goldberg EL, Araldi E, Ding W, Fan Y, Thompson BM, Singh AK, Li Q, Tellides G, Ordovás-Montanes J, García Milian R, Dixit VD, Ikonen E, Suárez Y, Fernández-Hernando C. Zhang X, et al. Proc Natl Acad Sci U S A. 2021 Nov 23;118(47):e2107682118. doi: 10.1073/pnas.2107682118. Proc Natl Acad Sci U S A. 2021. PMID: 34782454 Free PMC article.
Mepolizumab targets multiple immune cells in aspirin-exacerbated respiratory disease.
Buchheit KM, Lewis E, Gakpo D, Hacker J, Sohail A, Taliaferro F, Berreondo Giron E, Asare C, Vukovic M, Bensko JC, Dwyer DF, Shalek AK, Ordovas-Montanes J, Laidlaw TM. Buchheit KM, et al. J Allergy Clin Immunol. 2021 Aug;148(2):574-584. doi: 10.1016/j.jaci.2021.05.043. Epub 2021 Jun 16. J Allergy Clin Immunol. 2021. PMID: 34144111 Free PMC article. Clinical Trial.
Single-Cell Analyses of Colon and Blood Reveal Distinct Immune Cell Signatures of Ulcerative Colitis and Crohn's Disease.
Mitsialis V, Wall S, Liu P, Ordovas-Montanes J, Parmet T, Vukovic M, Spencer D, Field M, McCourt C, Toothaker J, Bousvaros A; Boston Children’s Hospital Inflammatory Bowel Disease Center; Brigham and Women’s Hospital Crohn’s and Colitis Center; Shalek AK, Kean L, Horwitz B, Goldsmith J, Tseng G, Snapper SB, Konnikova L. Mitsialis V, et al. Gastroenterology. 2020 Aug;159(2):591-608.e10. doi: 10.1053/j.gastro.2020.04.074. Epub 2020 May 16. Gastroenterology. 2020. PMID: 32428507 Free PMC article.
Single-Cell Analysis of the Liver Epithelium Reveals Dynamic Heterogeneity and an Essential Role for YAP in Homeostasis and Regeneration.
Pepe-Mooney BJ, Dill MT, Alemany A, Ordovas-Montanes J, Matsushita Y, Rao A, Sen A, Miyazaki M, Anakk S, Dawson PA, Ono N, Shalek AK, van Oudenaarden A, Camargo FD. Pepe-Mooney BJ, et al. Cell Stem Cell. 2019 Jul 3;25(1):23-38.e8. doi: 10.1016/j.stem.2019.04.004. Epub 2019 May 9. Cell Stem Cell. 2019. PMID: 31080134 Free PMC article.