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Hybrid molecules combining GABA-A and serotonin 5-HT6 receptors activity designed to tackle neuroinflammation associated with depression.
Marcinkowska M, Mordyl B, Fajkis-Zajaczkowska N, Siwek A, Karcz T, Gawalska A, Bucki A, Żmudzki P, Partyka A, Jastrzębska-Więsek M, Pomierny B, Walczak M, Smolik M, Pytka K, Mika K, Kotańska M, Kolaczkowski M. Marcinkowska M, et al. Among authors: zmudzki p. Eur J Med Chem. 2023 Feb 5;247:115071. doi: 10.1016/j.ejmech.2022.115071. Epub 2022 Dec 29. Eur J Med Chem. 2023. PMID: 36603509
New 8-aminoalkyl derivatives of purine-2,6-dione with arylalkyl, allyl or propynyl substituents in position 7, their 5-HT1A, 5-HT2A, and 5-HT7 receptor affinity and pharmacological evaluation.
Chłoń-Rzepa G, Zmudzki P, Satała G, Duszyńska B, Partyka A, Wróbel D, Jastrzębska-Więsek M, Wesołowska A, Bojarski AJ, Pawłowski M, Zajdel P. Chłoń-Rzepa G, et al. Among authors: zmudzki p. Pharmacol Rep. 2013;65(1):15-29. doi: 10.1016/s1734-1140(13)70960-5. Pharmacol Rep. 2013. PMID: 23563020 Free article.
Arylsulfonamide derivatives of (aryloxy)ethyl pyrrolidines and piperidines as α1-adrenergic receptor antagonist with uro-selective activity.
Rak A, Canale V, Marciniec K, Żmudzki P, Kotańska M, Knutelska J, Siwek A, Stachowicz G, Bednarski M, Nowiński L, Zygmunt M, Zajdel P, Sapa J. Rak A, et al. Among authors: zmudzki p. Bioorg Med Chem. 2016 Nov 1;24(21):5582-5591. doi: 10.1016/j.bmc.2016.09.017. Epub 2016 Sep 10. Bioorg Med Chem. 2016. PMID: 27658792
Aminoalkyl Derivatives of 8-Alkoxypurine-2,6-diones: Multifunctional 5-HT1A /5-HT7 Receptor Ligands and PDE Inhibitors with Antidepressant Activity.
Chłoń-Rzepa G, Zagórska A, Żmudzki P, Bucki A, Kołaczkowski M, Partyka A, Wesołowska A, Kazek G, Głuch-Lutwin M, Siwek A, Starowicz G, Pawłowski M. Chłoń-Rzepa G, et al. Among authors: zmudzki p. Arch Pharm (Weinheim). 2016 Dec;349(12):889-903. doi: 10.1002/ardp.201600260. Epub 2016 Nov 21. Arch Pharm (Weinheim). 2016. PMID: 27869315
Synthesis and activity of di- or trisubstituted N-(phenoxyalkyl)- or N-{2-[2-(phenoxy)ethoxy]ethyl}piperazine derivatives on the central nervous system.
Pańczyk K, Pytka K, Jakubczyk M, Rapacz A, Sałat K, Furgała A, Siwek A, Głuch-Lutwin M, Gryboś A, Słoczyńska K, Pękala E, Żmudzki P, Bucki A, Kołaczkowski M, Żelaszczyk D, Marona H, Waszkielewicz AM. Pańczyk K, et al. Among authors: zmudzki p. Bioorg Med Chem Lett. 2018 Jun 15;28(11):2039-2049. doi: 10.1016/j.bmcl.2018.04.059. Epub 2018 Apr 25. Bioorg Med Chem Lett. 2018. PMID: 29730027
68 results