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Alzheimer's disease linked Aβ42 exerts product feedback inhibition on γ-secretase impairing downstream cell signaling.
Zoltowska KM, Das U, Lismont S, Enzlein T, Maesako M, Houser MC, Franco ML, Özcan B, Moreira DG, Karachentsev D, Becker A, Hopf C, Vilar M, Berezovska O, Mobley W, Chávez-Gutiérrez L. Zoltowska KM, et al. bioRxiv [Preprint]. 2024 Apr 23:2023.08.02.551596. doi: 10.1101/2023.08.02.551596. bioRxiv. 2024. PMID: 37577527 Free PMC article. Preprint.
Aβ profiles generated by Alzheimer's disease causing PSEN1 variants determine the pathogenicity of the mutation and predict age at disease onset.
Petit D, Fernández SG, Zoltowska KM, Enzlein T, Ryan NS, O'Connor A, Szaruga M, Hill E, Vandenberghe R, Fox NC, Chávez-Gutiérrez L. Petit D, et al. Among authors: zoltowska km. Mol Psychiatry. 2022 Jun;27(6):2821-2832. doi: 10.1038/s41380-022-01518-6. Epub 2022 Apr 1. Mol Psychiatry. 2022. PMID: 35365805 Free PMC article.
Exploring the origins of nucleation.
Zoltowska KM, Chávez-Gutiérrez L. Zoltowska KM, et al. Elife. 2021 Mar 10;10:e67269. doi: 10.7554/eLife.67269. Elife. 2021. PMID: 33688830 Free PMC article.
73 results