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Synthesis and evaluation of a new class of MIF-inhibitors in activated macrophage cells and in experimental septic shock in mice.
Garai J, Radnai B, Vámos E, Kovács D, Vántus VB, Rumbus Z, Pákai E, Garami A, Gulyás-Fekete G, Agócs A, Krekó M, Zaman K, Prókai L, Őrfi L, Jakus PB, Lóránd T. Garai J, et al. Among authors: orfi l. Eur J Med Chem. 2023 Feb 5;247:115050. doi: 10.1016/j.ejmech.2022.115050. Epub 2022 Dec 28. Eur J Med Chem. 2023. PMID: 36587420 Free article.
HER2 Mediates PSMA/mGluR1-Driven Resistance to the DS-7423 Dual PI3K/mTOR Inhibitor in PTEN Wild-type Prostate Cancer Models.
Gómez V, Galazi M, Weitsman G, Monypenny J, Al-Salemee F, Barber PR, Ng K, Beatson R, Szokol B, Orfi L, Mullen G, Vanhaesebroeck B, Chowdhury S, Leung HY, Ng T. Gómez V, et al. Among authors: orfi l. Mol Cancer Ther. 2022 Apr 1;21(4):667-676. doi: 10.1158/1535-7163.MCT-21-0320. Mol Cancer Ther. 2022. PMID: 35086953 Free PMC article.
EGFR Alterations Influence the Cetuximab Treatment Response and c-MET Tyrosine-Kinase Inhibitor Sensitivity in Experimental Head and Neck Squamous Cell Carcinomas.
Nelhűbel GA, Cserepes M, Szabó B, Türk D, Kárpáti A, Kenessey I, Rásó E, Barbai T, Hegedűs Z, László V, Szokol B, Dobos J, Őrfi L, Tóvári J. Nelhűbel GA, et al. Among authors: orfi l. Pathol Oncol Res. 2021 May 3;27:620256. doi: 10.3389/pore.2021.620256. eCollection 2021. Pathol Oncol Res. 2021. PMID: 34257586 Free PMC article.
Tetralone derivatives are MIF tautomerase inhibitors and attenuate macrophage activation and amplify the hypothermic response in endotoxemic mice.
Garai J, Krekó M, Őrfi L, Jakus PB, Rumbus Z, Kéringer P, Garami A, Vámos E, Kovács D, Bagóné Vántus V, Radnai B, Lóránd T. Garai J, et al. Among authors: orfi l. J Enzyme Inhib Med Chem. 2021 Dec;36(1):1357-1369. doi: 10.1080/14756366.2021.1916010. J Enzyme Inhib Med Chem. 2021. PMID: 34225560 Free PMC article.
119 results