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Oral supplementation of nicotinamide riboside alters intestinal microbial composition in rats and mice, but not humans.
Peluso AA, Lundgaard AT, Babaei P, Mousovich-Neto F, Rocha AL, Damgaard MV, Bak EG, Gnanasekaran T, Dollerup OL, Trammell SAJ, Nielsen TS, Kern T, Abild CB, Sulek K, Ma T, Gerhart-Hines Z, Gillum MP, Arumugam M, Ørskov C, McCloskey D, Jessen N, Herrgård MJ, Mori MAS, Treebak JT. Peluso AA, et al. Among authors: orskov c. NPJ Aging. 2023 Apr 3;9(1):7. doi: 10.1038/s41514-023-00106-4. NPJ Aging. 2023. PMID: 37012386 Free PMC article.
Evaluation of commercially available glucagon receptor antibodies and glucagon receptor expression.
Bomholt AB, Johansen CD, Christensen JB, Kjeldsen SAS, Galsgaard KD, Winther-Sørensen M, Serizawa R, Hornum M, Porrini E, Pedersen J, Ørskov C, Gluud LL, Sørensen CM, Holst JJ, Albrechtsen R, Wewer Albrechtsen NJ. Bomholt AB, et al. Among authors: orskov c. Commun Biol. 2022 Nov 22;5(1):1278. doi: 10.1038/s42003-022-04242-7. Commun Biol. 2022. PMID: 36418521 Free PMC article.
Glucagon receptor antagonism impairs and glucagon receptor agonism enhances triglycerides metabolism in mice.
Galsgaard KD, Elmelund E, Johansen CD, Bomholt AB, Kizilkaya HS, Ceutz F, Hunt JE, Kissow H, Winther-Sørensen M, Sørensen CM, Kruse T, Lau JF, Rosenkilde MM, Ørskov C, Christoffersen C, Holst JJ, Wewer Albrechtsen NJ. Galsgaard KD, et al. Among authors: orskov c. Mol Metab. 2022 Dec;66:101639. doi: 10.1016/j.molmet.2022.101639. Epub 2022 Nov 15. Mol Metab. 2022. PMID: 36400402 Free PMC article.
Novel agonist and antagonist radioligands for the GLP-2 receptor. Useful tools for studies of basic GLP-2 receptor pharmacology.
Gadgaard S, van der Velden WJC, Schiellerup SP, Hunt JE, Gabe MBN, Windeløv JA, Boer GA, Kissow H, Ørskov C, Holst JJ, Hartmann B, Rosenkilde MM. Gadgaard S, et al. Among authors: orskov c. Br J Pharmacol. 2022 May;179(9):1998-2015. doi: 10.1111/bph.15766. Epub 2022 Jan 11. Br J Pharmacol. 2022. PMID: 34855984 Free PMC article.
Hepatocyte-specific perturbation of NAD+ biosynthetic pathways in mice induces reversible nonalcoholic steatohepatitis-like phenotypes.
Dall M, Hassing AS, Niu L, Nielsen TS, Ingerslev LR, Sulek K, Trammell SAJ, Gillum MP, Barrès R, Larsen S, Poulsen SS, Mann M, Ørskov C, Treebak JT. Dall M, et al. Among authors: orskov c. J Biol Chem. 2021 Dec;297(6):101388. doi: 10.1016/j.jbc.2021.101388. Epub 2021 Nov 8. J Biol Chem. 2021. PMID: 34762911 Free PMC article.
Amino acids differ in their capacity to stimulate GLP-1 release from the perfused rat small intestine and stimulate secretion by different sensing mechanisms.
Modvig IM, Kuhre RE, Jepsen SL, Xu SFS, Engelstoft MS, Egerod KL, Schwartz TW, Ørskov C, Rosenkilde MM, Holst JJ. Modvig IM, et al. Among authors: orskov c. Am J Physiol Endocrinol Metab. 2021 May 1;320(5):E874-E885. doi: 10.1152/ajpendo.00026.2021. Epub 2021 Mar 1. Am J Physiol Endocrinol Metab. 2021. PMID: 33645250 Free article.
Glucagon acutely regulates hepatic amino acid catabolism and the effect may be disturbed by steatosis.
Winther-Sørensen M, Galsgaard KD, Santos A, Trammell SAJ, Sulek K, Kuhre RE, Pedersen J, Andersen DB, Hassing AS, Dall M, Treebak JT, Gillum MP, Torekov SS, Windeløv JA, Hunt JE, Kjeldsen SAS, Jepsen SL, Vasilopoulou CG, Knop FK, Ørskov C, Werge MP, Bisgaard HC, Eriksen PL, Vilstrup H, Gluud LL, Holst JJ, Wewer Albrechtsen NJ. Winther-Sørensen M, et al. Among authors: orskov c. Mol Metab. 2020 Dec;42:101080. doi: 10.1016/j.molmet.2020.101080. Epub 2020 Sep 13. Mol Metab. 2020. PMID: 32937194 Free PMC article.
Secretion of parathyroid hormone may be coupled to insulin secretion in humans.
Sass MR, Wewer Albrechtsen NJ, Pedersen J, Hare KJ, Borbye-Lorenzen N, Kiss K, Vilsbøll T, Knop FK, Poulsen SS, Jørgensen NR, Holst JJ, Ørskov C, Hartmann B. Sass MR, et al. Among authors: orskov c. Endocr Connect. 2020 Jul;9(7):747-754. doi: 10.1530/EC-20-0092. Endocr Connect. 2020. PMID: 32698134 Free PMC article.
120 results